REVIEW   

Minerva Cardiology and Angiology 2025 Jan 23

DOI: 10.23736/S2724-5683.24.06655-9

Copyright © 2024 EDIZIONI MINERVA MEDICA

language: English

Prognostic utility of assessing ventricular-arterial coupling in arterial hypertension and cardiovascular diseases

Andrea VITALI ¹ ✉, Fouad A. ZOUEIN ^{2, 3, 4, 5}, George W. BOOZ ⁴, Raffaele ALTARA ^{6, 7}

¹ School of Medicine, Department of Clinical Internal, Anesthesiological and Cardiovascular Sciences, Sapienza University, Rome, Italy; ² Department of Pharmacology and Toxicology, Faculty of Medicine, American University of Beirut, Beirut, Lebanon; ³ Cardiovascular, Renal, and Metabolic Diseases Research Center of Excellence, American University of Beirut Medical Center, Riad El-Solh, Beirut, Lebanon; ⁴ School of Medicine, Department of Pharmacology and Toxicology, University of Mississippi Medical Center, Jackson, MS, USA; ⁵ Department of Signaling and Cardiovascular Pathophysiology, UMR-S 1180, INSERM, Paris-Saclay University, Orsay, France; ⁶ Department of Anatomy and Embryology, Faculty of Health, Medicine and Life Sciences, Maastricht University, Maastricht, the Netherlands; ⁷ School of Medicine, Department of Pathology, University of Mississippi Medical Center, Jackson, MS, USA

The assessment of myocardial function and its coupling with the arterial system, called ventricular-arterial coupling (VAC), is of paramount importance in many clinical fields, from arterial hypertension, which is the main cause of cardiovascular diseases and death, to heart failure. VAC has been the subject of studies for several decades both from an energetic cost and the impact it can exert on cardiovascular performance. Although more attention has been paid to the relationship between the left ventricle and the left arterial circuit in compromised hemodynamic stages, VAC has aroused interest in many other aspects of study, from its application in pathologies of the right sections of the heart to its clinical impact in prevention and cardiovascular risk factors. In this review we will focus on the importance of the hemodynamic data of the VAC in various clinical contexts and its possible applications in the future as a diagnostic and prognostic parameter in the cardiac clinic.

KEY WORDS: Heart; Athletic performance; Arteries; Hypertension; Cardiovascular diseases; Aging