ORIGINAL ARTICLE   Free access

Minerva Anestesiologica 2019 August;85(8):822-9

DOI: 10.23736/S0375-9393.19.13388-3

Copyright © 2019 EDIZIONI MINERVA MEDICA

language: English

Comparison of the incidence of perioperative cardiovascular risk events among patients with and without a history of neoadjuvant chemotherapy

Wen ZHANG ¹, Kangjie XIE ¹, Shuang FU ¹, Huifang JIANG ¹, Man FANG ¹, Yanhong LIAN ¹, Wujun GENG ², Jun FANG ¹ ✉

¹ Department of Anesthesiology, Zhejiang Cancer Hospital, Hangzhou, China; ² Department of Anesthesiology, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China

BACKGROUND: Chemotherapy predisposes individuals to increased risk for future cardiac events.
METHODS: In order to verify the hypothesis that neoadjuvant chemotherapy may be a risk factor for perioperative cardiovascular events, 122 patients who underwent radical mastectomy with general anesthesia were separated into two groups, the N group (neoadjuvant chemotherapy group) and the C group (control group), according to neoadjuvant chemotherapy history. Cardiovascular events were recorded in 24 hours after surgery.
RESULTS: There were no differences in demographic characteristics such as age, body mass index and electrocardiogram between the two groups. The N group had higher atherosclerosis index, lower preoperative echocardiographic ejection fraction and hemoglobin values than the C group. The N group had significantly higher incidence of cardiovascular risk events (16.1%) than the C group (5%) (P<0.05). After binary logistic regression, neoadjuvant chemotherapy was identified as a risk factor of cardiovascular risk events.
CONCLUSIONS: Patients who underwent neoadjuvant chemotherapy prior to radical mastectomy were more prone to cardiovascular risk events than those without chemotherapy history.

KEY WORDS: Breast neoplasms; Cardiovascular abnormalities; Drug therapy; Anesthesia, general