ORIGINAL ARTICLE   

Acta Phlebologica 2025 April;26(1):40-4

DOI: 10.23736/S1593-232X.24.00629-5

Copyright © 2024 EDIZIONI MINERVA MEDICA

lingua: Inglese

Efficacy of a nutraceutical combination therapy for improving symptoms and quality of life in chronic venous disease

Daniela MAZZACCARO ¹ ✉, Paolo C. RIGHINI ¹, Alfredo MODAFFERI ¹, Marina GALLIGANI ¹, Fabiana FANCOLI ¹, Giovanni MALACRIDA ¹, Giovanni NANO ^{1, 2}

¹ Operative Unit of Vascular Surgery, IRCCS Policlinico San Donato, San Donato Milanese, Milan, Italy; ² Department of Biomedical Sciences for Health, University of Milan, Milan, Italy

BACKGROUND: To evaluate the effectiveness of a nutraceutical combination therapy (Flebo Up^®) on relieving symptoms and signs of chronic venous disease (CVD), compared with a group of patients treated with a reference drug (Daflon^®).
METHODS: Data of patients affected by CVD class C0-C4 according to the CEAP classification who took either Daflon^® 500 mg twice a day or Flebo Up^® 500 mg daily for at least 3 months were analyzed. A P value <0.05 was considered statistically significant.
RESULTS: Data of 160 patients (80 each group) were analyzed. After 1 month, patients treated with Flebo Up^® experienced a significant reduction of leg pain (64.7%), of heaviness (59.6%), of nocturnal cramps 65.1% and of leg circumference, if compared to the enrollment status and also to the group of patients treated with Daflon^® (P<0.001).
CONCLUSIONS: After one month, Flebo Up^® induced a significant reduction of leg pain, heaviness, nocturnal cramps and leg circumference, acting more rapidly than Daflon^®.

KEY WORDS: Dietary supplements; Quality of Life; Diosmin