ORIGINAL ARTICLE   

Minerva Pediatrics 2025 April;77(2):130-8

DOI: 10.23736/S2724-5276.22.06712-X

Copyright © 2022 EDIZIONI MINERVA MEDICA

language: English

Respiratory syncytial virus specific immunoglobulin G4 antibodies and atopic diseases in children

Helena TESARI CRNKOVIĆ ^{1, 2} ✉, Krešo BENDELJA ³, Romana GJERGJA JURAŠKI ^{2, 4}, Mirjana TURKALJ ^{2, 4, 5}

¹ Department of Pediatrics, General County Hospital Požega, Požega, Croatia; ² Faculty of Medicine, J. J. Strossmayer University of Osijek, Osijek, Croatia; ³ Center for Research and Knowledge Transfer in Biotechnology, University of Zagreb, Zagreb, Croatia; ⁴ Department of Pulmonology and Allergology, Children’s Hospital Srebrnjak, Zagreb, Croatia; ⁵ Faculty of Medicine, Catholic University of Croatia, Zagreb, Croatia

BACKGROUND: It has been proposed that RSV infection stimulates RSV specific IgE and IgG4 production as a hallmark of Th2 immune response, which can contribute to the development of allergic sensitization and atopic diseases. This study intends to examine the occurrence of atopic diseases in children (wheezing bronchitis, food allergy, atopic dermatitis) and their connection with RSV specific IgE and IgG4 during the first two years of life.
METHODS: Prospective follow-up from the moment of birth was performed in 127 children with positive RSV specific IgG antibodies at age one and 92 children were followed-up until two years of age. The assessment included a structured interview, clinical examination, total blood eosinophils, serum total IgE and allergen specific IgE antibodies, RSV specific IgG, IgG3, IgG4 and IgE antibodies.
RESULTS: Significant correlation was found between positive RSV IgG4 antibodies at year one and atopic dermatitis (Tau_b=0.201, P=0.025), as well as food allergy development (Tau_b=0.205, P=0.023). RSV specific IgG4 antibodies to RSV at year one showed significant prediction of increased total and/or allergen specific IgE (odds ratio 2.73 and 95% confidence interval 1.07 - 7.00, P=0.036). In our regression model, the children who had positive RSV IgG4 antibodies had a 2.73 times higher likelihood of having increased positive total and/or allergen specific IgE during the first two years of life.
CONCLUSIONS: RSV specific IgG4 antibodies could be a marker of risk for the development of atopic sensitization to inhaled and food allergens, development of food allergy and atopic dermatitis in atopic children.

KEY WORDS: Respiratory syncytial viruses; Immunoglobulin G; Dermatitis, allergic contact; Food hypersensitivity; Dermatitis, atopic