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Gazzetta Medica Italiana Archivio per le Scienze Mediche 2018 July-August;177(7-8):367-73

DOI: 10.23736/S0393-3660.17.03668-3

Copyright © 2017 EDIZIONI MINERVA MEDICA

language: English

Association between epicardial adipose tissue and coronary no-reflow phenomenon

Levent CERIT

Department of Cardiology, Near East University, Nicosia, Cyprus


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BACKGROUND: Epicardial adipose tissue (EAT) is a metabolically active endocrine and paracrine organ that secretes several pro-inflammatory and pro-atherogenic cytokines and hormones, resulting in vascular, immunological, and inflammatory responses. Coronary no-reflow phenomenon (CNP) is associated with a increased risk of early congestive heart failure, malignant arrhythmias, mechanical complications including cardiac rupture, and post-acute myocardial infarction. This study was conducted with the aim to evaluate the association between EAT and CNP.
METHODS: The medical records of consecutive patients with ST elevation myocardial infarction, who underwent primer percutaneous intervention, were retrospectively reviewed. The study group consisted of 249 patients. Taking into consideration the inclusion criteria, 63 patients with CNP and 184 patients without CNP were included in the study. Study population divided into two groups in according to EAT thickness (group I≥5 mm, group I<5 mm). Biochemical, clinical, echocardiographic and angiographic parameters were evaluated in all patients.
RESULTS: Group I had higher prevalence of hypertension, hyperlipidemia, diabetes mellitus, and CNP. On univariate analysis, HT, DM, HL, and EAT thickness were associated with CNP. On multivariate analysis DM, HL, and EAT thickness were independent predictors for CNP (OR=1.974; 95% CI: 1.253-3.079; P<0.001, OR=2.367; 95% CI: 1.849-4.183; P<0.001, OR=1.839; 95% CI: 1.386-2.943; P<0.001, respectively).
CONCLUSIONS: In our study, we have founded that increased EAT thickness was independent predictor for CNP.


KEY WORDS: No-reflow phenomenon - Adipose tissue - Diabetes mellitus - Hyperlipidemias

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