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Italian Journal of Emergency Medicine 2020 April;9(1):29-34

DOI: 10.23736/S2532-1285.20.00019-1

Copyright © 2020 THE AUTHORS

This is an open access article distributed under the terms of the CC BY-NC-ND 4.0 license which allows users to copy and distribute the manuscript, as long as this is not done for commercial purposes and further does not permit distribution of the manuscript if it is changed or edited in any way, and as long as the user gives appropriate credits to the original author(s) and the source (with a link to the formal publication through the relevant DOI) and provides a link to the license.

language: English

Ringer lactate versus saline solution for resuscitation of sepsis and septic shock

Antonio PAGANO 1 , Giovanni PORTA 1, Giorgio BOSSO 1, Valerio ROSATO 2, Enrico ALLEGORICO 1, Claudia SERRA 1, Alfonso SFORZA 3, Fiorella PALADINO 4, Fabio G. NUMIS 1

1 Santa Maria delle Grazie Hospital, Naples, Italy; 2 University of Salerno, Salerno, Italy; 3 AORN dei Colli, Naples, Italy; 4 AORN Cardarelli, Naples, Italy



BACKGROUND: Sepsis and septic shock are the main causes of morbidity and mortality in critically ill patients. Fluid resuscitation is a cornerstone of therapy. The aim of this study was to compare saline solution to Ringer lactate in resuscitation of patients with sepsis and septic shock.
METHODS: We randomly assigned patients who had been admitted to the emergency department for sepsis or septic shock to receive either ringer lactate or normal saline for intravascular-fluid resuscitation. The primary outcome measure was in-hospital death from any cause. Second outcomes were requirement of mechanical ventilation and worsening of renal function.
RESULTS: Among the 84 patients, 35 receive Ringer Lactate and 49 saline solution. The two groups had similar baseline characteristics. There were 8 deaths in the Ringer Lactate group, as compared with 28 deaths in the saline group (27.6% versus 63%; P=0.003). There were no significant differences between the groups in need of mechanical ventilation (4.5±6.1 and 4.3±5.7, respectively; P=0.74), or worsening of renal function.
CONCLUSIONS: Patients with sepsis or septic shock resuscitated using lactated Ringer had a lower mortality than those resuscitated with 0.9% NaCl solution.


KEY WORDS: Sepsis; Shock; Ringer’s lactate

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