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Management of gastric cancer
Recent advances
Maurizio DEGIULI
Hardcover € 26,12
DESCRIPTION
The book documents the status of the art of the actual knowledge of multiple aspects related to gastric cancer. Although it has been edited by a surgeon, it takes inside the awareness that surgery is only one ring of the complex chain of the different items of this disease.
The first parts of the text are facing epidemiology, molecular biology, genetics and the relationships with Helicobacter pylori infection.
Then, after evaluating specific pathological aspects and problems related with modern endoscopy and endo-ultrasonography, different methods of treatments are examined. Multimodality treatment targeted on each single patient's and tumor's features represents the actual gold standard, while genetic therapy should be considered as the future goal of research worldwide.
At the moment, improvement of early diagnosis and development of endoscopic resection techniques (EMR, ESD), early detection of responders to neoadjuvant chemotherapy in advanced cancers and preoperative detection through genomic profiling of patients with high risk of lymph node metastasis in order to modulate the extent of nodal dissection are the goals of multidisciplinary teams active in reference centers.
ABOUT THE AUTHORS
Maurizio DEGIULI. Interdisciplinary Group for the Cure of Gastric Cancer, Coordinator of the Italian Gastric Cancer Study Group, SCDU Chirurgia Generale 1, ASO San Giovanni Battista, Turin, Italy
In early 90s surgery of gastric cancer represented my greatest interest. I had been reading with enormous involvement all international literature regarding this field, particularly extended lymph node dissection. In 1994 I visited for the first time the National Cancer Center Hospital in Tokyo. I had been invited by Mitsuru Sasako and have been staying there for a couple of months, learning much about the procedure, the methods and the quality control system. I came back to Tokyo other three times. Since then my experience on surgical treatment of gastric cancer has grown as much as I have extended my net of knowledge also outside surgery. Recently all of us facing the problems related to gastric cancer have learned that Surgery is only one ring of the complex chain of multiple aspects of the disease. Multimodality treatment targeted on each single patient’s and tumor’s features represents the actual gold standard, while genetic therapy should be the future goal of the research. At the moment, improvement of early diagnosis which can guarantee a complete recovery practically in all cases, early detection of responders to neoadjuvant chemotherapy for advanced cancers and preoperative detection with genomic profiling of patients with high risk of lymph nodes metastases are the goals of multidisciplinary teams active in reference centers.
CHAPTER INDEX
EPIDEMIOLOGY
MOLECULAR BIOLOGY AND GENETICS
HELICOBACTER PYLORI INFECTION AND PRECANCEROUS LESIONS
PATHOLOGY
ENDOSCOPY AND DIAGNOSIS
SURGERY
CHEMOTHERAPY
APPENDIX
