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Principles for next generation anti-cancer immunotherapy


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The clinical success of immune chechpoint blockade with anty cytotoxic T-lymphocyte associated antigen (CTLA)-4 and anti-programmed death (P-D)-1/PD-ligand (L)1 inhibitor in melanoma and other canceers has encouraged increasing development of other immunotherapies, particularly monoclonal antibodies with other immune targets, adoptive cell transfer and vaccines. Nowadays immunotherapy is considered the fourth pillar in the treatment against cancer together with surgery, chemotherapy, and radiotherapy. After the first approval of ipilimumab in 2011 for the metastatic melanoma patient, several additional successes were reached in other cancer diseases like those of lung, kidney, head and neck, urotherlial, bladder, colon with microsatellite instability, Hodgkin lymphoma, etc. The common characteristic of immunotherapy is the possibility to reach a long-term benefit making chronic a bad disease. In the next future combination strategies and innovative approaches could increase the efficacy of such strategy.


Fundamentals of tumor immunology

Giuseppe V. Masucci, Lisa Villabona

Immune oncology and immune responsiveness

Ena Wang, Francesco M. Marincola

The role of the tumor microenvironment

Anastasia Lanzi, Jérôme Galon

Biomarkers in immunotherapy

Giuseppe Palmieri, Alfredo Budillon, Nicola Normanno

Mechanisms of resistance to immunotherapies

Katerina Politi, Maria Libera Ascierto

Combination strategies

Ryan J. Sullivan, Omid Hamid, Paolo Ascierto

Immunotherapy in metastatic melanoma

Claudia Trojaniello, Paolo A. Ascierto

Immunotherapy and lung cancer

Cesare Gridelli, Antonio Passaro, Francesca Casaluce, Filippo de Marinis

Immunotherapy in RCC

Paul Nathan

Immunotherapy in urothelial cancers and renal cell carcinoma

Sergio Bracarda, Claudia Caserta, Serena Macrini, Claudia Mosillo, Federica Urbano

Immunotherapy in head and neck cancer

Nerina Denaro, Marco C. Merlano

Management of immune checkpoint inhibitor side effects

Douglas B. Johnson, Yara Abdou, Igor Puzanov

The role of the microbiome in cancer immunotherapy

Carlotta Catozzi, Giorgio Trinchieri, Luigi Nezi

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