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Gut microbiota and gastrointestinal tract, liver and pancreas

From physiology to pathology


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The human organism is colonized by an enormous number of microbes, both on its surface and its inside. The set of microorganisms living in our gut is defined gut microbiota, which is considered now a functional organ of our body. Gut microbiota plays a key role in regulating both health and disease; its quantitative and/or qualitative variations, by altering the homeostasis between microbes and host, may lead to the onset of various diseases. Dis¬orders associated with the impairment of gut microbiota include functional gastrointestinal diseases, intestinal infectious diseases, inflammatory bowel disease (IBD), liver and pancreatic diseases, gastrointestinal malignancies, but also metabolic syndrome and diabetes and obesity, allergic diseases, autism, and others. The intestinal microbiota is considered a signaling hub that integrates environmental inputs, such as diet, with genetic and immune signals to affect the host’s metabolism, immunity, including autoimmunity and autoinflammation and elaborate networks linked to several organs. There is increasing interest on gut microbiota modulation as both a preventive strategy or as a therapeutic option in different gastrointestinal, hepatic and systemic diseases. The continuous use of words such as gastrointestinal microbiome, probiotics, prebiotics, fecal microbiota transplantation also through the media communications, suggests that this book, which is totally dedicated to the main relationships between gut echological system and diseases based on the most recent literature, could be a useful instrument both for research and for clinical practice in medicine and biology.
The gut microbiota: its anatomy and physiology over a lifetime

The development of gut microbiota
Factors modulating microbiota health
Physiological functions of the gut microbiota
Gut microbiota, obesity and metabolic disorders
Gut microbiota in obese patients: a matter of diet
Gut microbiota and metabolic disorders: pathogenesis
Gut microbiota and gastric disease
Gastric microbiota: HP and non-HP bacteria and their interaction
Gastric microbiota in the development of non-atrophic gastritis, intestinal metaplasia and gastric cancer
Gastric microbiota and dyspepsia
Exogenous interference on the gastric microbiota: proton pump inhibitors and diet
Gut microbiota and functional diseases of the gastrointestinal tract
Esophageal microbiota and functional GI disorders
Gastric microbiota and functional GI disorders
Duodenal microbiota and functional GI disorders
Bowel microbiota and functional GI disorders
Gut microbiota and inflammatory bowel disease: so far so gut!
The pathogenesis of IBD and the discovery of the key role of microbiome
Past perspective of the role of microbiota in IBD
Current evidences about dysbiosis in IBD
Diet as primary determinant for microbiome
Clinical utility of medications affecting microbiome in IBD
Towards a more robust manipulation of the microbiome in therapeutic armamentarium of IBD: probiotics, prebiotics, fecal microbiota transplantation and emerging dietary intervention
Beyond or more on microbiome: emerging role of virus and yeast
Gut microbiota and the liver
The gut microbiota in chronic liver diseases
IP and liver damage
Gut microbiota in chronic liver diseases
Gut microbiota and pancreatic diseases
Role of microbiota in acute pancreatitis
Role of microbiota in autoimmune pancreatitis
Role of the gut microbiota in chronic pancreatitis
Role of microbiota in pancreatic cancer
How to modulate gut microbiota: diet, preprobiotics or antibiotics?
Fecal microbiota transplantation: past, present and future perspectives
Historical overview
Pathophysiology of FMT
Procedural aspects
FMT in IBS and other functional bowel disorders
FMT beyond gastroenterological disorders
Future perspectives

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