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  THE MANAGEMENT OF THORACIC TYPE A DISSECTIONS 

Italian Journal of Vascular and Endovascular Surgery 2011 September;18(3):181-6

Copyright © 2011 EDIZIONI MINERVA MEDICA

lingua: Inglese

Potential role of MicroRNAs in thoracic aortic dissection

Zou S., Liao M., Wei X., Dong J., Jing Z

Department of Vascular Surgery, Changhai Hospital the Second Military Medical University, Shanghai, China


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In this review, we describe the recent advances in the understanding of the role of microRNAs (miRNAs) in thoracic aortic dissection (TAD), a life-threatening disease with high mortality. Until now, little was known about the miRNA profile and the role of miRNAs in the pathogenesis of TAD. But previous studies have discovered some differentially expressed miRNAs in TAD, such as miR-143/145, miR-491-3p, miR-488, miR-125b, miR-29 and miR-22, and demonstrated that they are associated with many pathophysiological processes taking place in dissected aorta. There’re also some other studies showing that miRNAs play important roles in the regulation of the these pathophysiological processes, such as the changes of the vascular smooth muscle cell (VSMC) functions, extracellular matrix (ECM) metabolism, inflammation, reaction to oxidative stress, hypertension, and shear stress. These studies provide exciting and novel observations suggesting that detailed analysis of the role of all miRNAs differentially expressed in TAD will have a significant impact on our understanding of the disease, and it seems likely that miRNA research will lead to the development of new therapeutic strategies in TAD.

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