ORIGINAL ARTICLES  SELECTED PAPERS FROM SICVE NATIONAL CONGRESS 2009 

Italian Journal of Vascular and Endovascular Surgery 2010 September;17(3):153-6

Copyright © 2010 EDIZIONI MINERVA MEDICA

lingua: Inglese

S100B and NSE as serical markers of subclinical cerebral damage after CEA and CAS

Tozzi M., Piffaretti G., Rivolta N., Maida S., Riva F., Buscarini E., Franchin M., Castelli P.

Unit of Vascular Surgery, Department of Surgical Science, University of Insubria, Varese, Italy

Aim. NSE and S100b are useful markers of cerebral injury in stroke and trauma but conflicting results have been published concerning the evaluation of subclinical damages. The aim of this work was to define a possible use of S100B and NSE as serical markers of subclinical cerebral damage after carotid endarterectomy (CEA) and carotid artery stenting (CAS).
Methods. Thirty patients with >70% carotid stenosis were enrolled (15 undergoing CEA and 15 undergoing CAS). Blood samples were drawn before surgery, 1 hour and 24 hours after opening the carotid clamp. NSE, S100b were determined using a commercial available test kit.
Results. Symptomatic patients show significantly higher NSE and S100b levels than asymtomatic in pre-operative. Postopera-tive S100b had statistically higher increase than NSE. S100b combined with NSE demonstrated significantly higher serical increase in patient undergoing CAS.
Conclusions. Combined measurement of S100b and NSE may improve the sensitivity of detecting subclinical cerebral damage. Higher increasing of serical markers in patient undergoing CAS show an higher morbidity. This study also demonstrate the persistence of an higher oxidative activity in intima after CAS.