Home > Riviste > The Journal of Sports Medicine and Physical Fitness > Fascicoli precedenti > Articles online first > The Journal of Sports Medicine and Physical Fitness 2022 Jul 11



Opzioni di pubblicazione
Per abbonarsi
Sottometti un articolo
Segnala alla tua biblioteca


Publication history
Per citare questo articolo


Review Article   

The Journal of Sports Medicine and Physical Fitness 2022 Jul 11

DOI: 10.23736/S0022-4707.22.13801-6


lingua: Inglese

The effect of aerobic exercise on metabolic parameters of patients with non-alcoholic fatty liver disease: systematic review and meta-analysis

Mehdi GHAFFARI 1 , Sajedeh SADEGHIYAN 1, Mohammad FARAMARZI 2, Masoud MOGHADDAM 3, Timothy BAGHURST 4

1 Department of Sport Sciences, Shahrekord University, Shahrekord, Iran; 2 Department of Exercise Physiology, Faculty of Sport Sciences, University of Isfahan, Isfahan, Iran; 3 Health and Human Performance, School of Health Sciences, College of Health and Human Services, Salisbury University, Salisbury, MD, USA; 4 Interdisciplinary Center for Athletic Coaching, College of Education, Florida State University, Tallahassee, FL, USA


INTRODUCTION: The aim of this study was to determine and evaluate the effect of aerobic exercise on fasting blood glucose, Insulin, Insulin resistance, Glycosylated hemoglobin (Hemoglobin A1C), Lipid profile as important indicators of non-alcoholic fatty liver disease.
EVIDENCE ACQUISITION: This research is a systematic review and meta-analysis that was conducted in 2021. For the present study, databases, ScienceDirect, PubMed, Scopus, science of Web, SID, Magiran and Google Scholar from 2010 to 2021, were searched along with keywords. After the initial screening, the full text of the articles was evaluated and the articles that met the inclusion criteria were analyzed. A total of 120 articles were reviewed, of which 16 articles met the criteria for entering the systematic review and meta-analysis. Accordingly, 710 people with fatty liver disease were divided into two groups of control and experimental group of 307 and 403 people, respectively. The mean age of the subjects in the present study was 52±10 years. The intervention effects were evaluated using the mean difference (MD) and the random effects model. Data were analyzed using effect size tests, bias analysis and heterogeneity analysis and by STATA software.
EVIDENCE SYNTHESIS: Meta-analysis results indicated that endurance training in general significantly reduced glucose levels (P = 0.004, SDM = -0.26, SE = 0.09), insulin (P = 0.01, SDM = -0.29, SE = 0.11), HOMA-IR (P = 0.01, SDM = -0.28, SE = 0.11), Hba1c (P = 0.001, SDM = -0.33, SE = 0.12), triglycerides (P = 0.02, SDM = -0.31, SE = 0.13) and LDL (P = 0.03, SDM = -0.21, SE = 0.1).
CONCLUSIONS: The results of meta-analysis did not show a significant effect on HDL levels after aerobic exercise in patients with fatty liver (P = 0.97, SDM = 0, SE = 0.09). Endurance training improves the levels of glucose, insulin, Hba1c, Homa-IR, triglyceride, and LDL; although, there was no significant change in HDL levels due to endurance training. However, there is still a need for further research in this area.

KEY WORDS: Endurance training; Metabolic parameters; Non-alcoholic fatty liver disease; Metabolic index; Insulin; Exercise intensity

inizio pagina