Home > Riviste > The Journal of Sports Medicine and Physical Fitness > Fascicoli precedenti > Articles online first > The Journal of Sports Medicine and Physical Fitness 2020 Dec 11

ULTIMO FASCICOLO
 

JOURNAL TOOLS

eTOC
Per abbonarsi
Sottometti un articolo
Segnala alla tua biblioteca
 

ARTICLE TOOLS

Publication history
Estratti
Permessi
Per citare questo articolo

 

 

The Journal of Sports Medicine and Physical Fitness 2020 Dec 11

DOI: 10.23736/S0022-4707.20.11898-X

Copyright © 2020 EDIZIONI MINERVA MEDICA

lingua: Inglese

Sedentary behavior, exercise and COVID-19: immune and metabolic implications in obesity and its comorbidities

Jabeur METHNANI 1, 2, 3 , Dorra AMOR 2, 4, Nariman YOUSFI 1, 5, Ali BOUSLAMA 2, 4, Asma OMEZZINE 2, 4, Ezdine BOUHLEL 1, 3

1 High Institute of Sport and Physical Education, University of Manouba, Ksar Said, Tunis, Tunisia; 2 LR12SP11, Biochemistry Department, Sahloul University Hospital, Sousse, Tunisia; 3 LR19ES09, Laboratoire de Physiologie de l'Exercice et Physiopathologie: de l’Intégré au Moléculaire Biologie, Médecine et Santé, Faculty of Medicine of Sousse, Sousse, Tunisia; 4 Faculty of Pharmacy of Monastir, University of Monastir, Monastir, Tunisia; 5 Research Laboratory Sport performance optimisation, National Center of Medicine and sport sciences


PDF


Many reports showed a dramatic decrease in the levels of physical activity during the current pandemic of SARS-COV-2. This has substantial immune and metabolic implications, especially in those at risk or with metabolic diseases including individuals with obesity and Type 2 diabetes. Here we discuss the route from physical inactivity to immune and metabolic aberrancies; focusing on how insulin resistance could represent an adaptive mechanism to the low physical activity levels and on how such an adaptive mechanism could shift to a pathognomonic feature of metabolic diseases, creating a vicious circle of immune and metabolic aberrancies. We provide a theoretical framework to the severe immunopathology of COVID-19 in patients with metabolic diseases. We finally discuss the idea of exercise as a potential adjuvant against COVID-19 and emphasize how even interrupting prolonged periods of sitting with short time breaks of very light activity could be a feasible strategy to limit the deleterious effects of the outbreak.


KEY WORDS: Sedentary behavior; Exercise; Immunity; SARS-COV-2; Infection

inizio pagina