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The Journal of Sports Medicine and Physical Fitness 2020 Jun 23

DOI: 10.23736/S0022-4707.20.10997-6


lingua: Inglese

Muscle damage and inflammatory status biomarkers after a 3-stage trail running race

Nicola GIOVANELLI 1, 2, Stefano LAZZER 1, 2 , Sabina CAUCI 1

1 Department of Medicine, University of Udine, Udine, Italy; 2 School of Sport Sciences, University of Udine, Udine, Italy


BACKGROUND: Participants in ultramarathon and multi-stage races are continuously increasing. A detailed knowledge of the time-course of the restoration in muscular, cardiac, and inflammatory biomarkers after a multi-stage race may help the design of training schedules focused to avoid adverse outcomes of repetitive high-intensity endurance exercise and athlete exhaustion. Thus, the aim of the study was to evaluate blood parameters and serum biomarkers associated to muscle damage and inflammation in athletes participating in a 3-stage competition.
METHODS: Ten runners concluded the race “Magraid” consisting of 3 stages of 22,48 and 20 km. Before (PRE), immediately after the end of the third stage (POST) and five days after the last stage (R5d), we collected blood samples.
RESULTS: Among others, at POST mean white blood cell (+57±42%; p=0.006), blood urea nitrogen 12 (+68±39%; p<0.001), creatinine (+17±12%, p=0.005), alanine aminotransferase (ALT, +104±69%; p=0.002), lactate dehydrogenase (LDH, +116±64%; p<0.001), creatine kinase (CK, +2044±1433%; p=0.011), CK-MBm (+1544±1007%; p=0.004), cardiac troponin I (cTnI, +85±129%; p=0.015), c-reactive protein (hsCRP, +2137±1660%; p=0.015) were higher than PRE. At R5d, ALT (+72±53%; p=0.010), LDH (+32±25%; p=0.006) and hsCRP (+252±234%; p=0.021) were still different compared with PRE.
CONCLUSIONS: A 3-stage trail running race induces an inflammatory status and muscle damage and functional consequences on some physiological systems that may not be completely recovered within a short period.

KEY WORDS: Myoglobin; Creatine kinase; Troponin; C-reactive protein; Inflammation; Endurance

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