Home > Riviste > The Journal of Sports Medicine and Physical Fitness > Fascicoli precedenti > The Journal of Sports Medicine and Physical Fitness 2019 January;59(1) > The Journal of Sports Medicine and Physical Fitness 2019 January;59(1):116-25

ULTIMO FASCICOLO
 

JOURNAL TOOLS

eTOC
Per abbonarsi
Sottometti un articolo
Segnala alla tua biblioteca
 

ARTICLE TOOLS

Publication history
Estratti
Permessi
Per citare questo articolo

 

ORIGINAL ARTICLE  EPIDEMIOLOGY AND CLINICAL MEDICINE 

The Journal of Sports Medicine and Physical Fitness 2019 January;59(1):116-25

DOI: 10.23736/S0022-4707.17.07862-8

Copyright © 2017 EDIZIONI MINERVA MEDICA

lingua: Inglese

Potential effect of exercise in ameliorating insulin resistance at transcriptome level

Zhigang HU 1 , Lei ZHOU 2, Tingting HE 1

1 Institute of Physical Education, Jiangxi Normal University, Nanchang, China; 2 Nanchang Institute of Science and Technology, Nanchang, China



BACKGROUND: Insulin resistance can lead to the pathogenesis of type 2 diabetes and exercise can increase insulin sensitivity. And different exercises may have different influences on the mitigation of insulin resistance. It is still unclear how exercise affects inherited insulin resistance at transcriptome level. The purpose of our study was to analyze the potential effects of exercise in ameliorating insulin resistance at transcriptome level.
METHODS: Herein, we analyzed two skeletal muscle transcriptome profiles, including gene profiles between inherited insulin resistant patients and matched healthy controls, and between trained and sedentary subjects (young and old subjects, respectively).
RESULTS: Analysis of differentially expressed genes revealed that 12 genes (SGK1, LOC101929876, MYL5, COL6A3, MLF1, LUM, MSTN, COL1A2, COL3A1, IL32, IRS2, and ID1) associated with insulin resistance were reversed by exercise in young subjects, while six genes (MSTN, CFHR1, PFKFB3, IL32, RGCC, and NMRK2) were identified in old subjects, suggesting that those genes play potential roles in insulin resistance response to exercise. In addition, we observed that two insulin resistance-related genes, MSTN and IL32, were identified in muscle cells of both young and old subjects, indicating their important roles in the mechanisms behind the beneficial effects of exercise on humans with inherited insulin resistance. Several pathways were also identified, such as “collagen metabolic process,” “focal adhesion,” and “negative regulation of myoblast differentiation.”
CONCLUSIONS: Taken together, our findings provide novel markers in insulin resistant patients and exercise, and some valuable information for future functional studies on how exercise ameliorating insulin resistance.


KEY WORDS: Exercise - Insulin resistance - Gene expression profiling - Wnt signaling pathway - Skeletal muscle

inizio pagina