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THE JOURNAL OF SPORTS MEDICINE AND PHYSICAL FITNESS

Rivista di Medicina, Traumatologia e Psicologia dello Sport


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ORIGINAL ARTICLE  EPIDEMIOLOGY AND CLINICAL MEDICINE


The Journal of Sports Medicine and Physical Fitness 2017 May;57(5):670-7

DOI: 10.23736/S0022-4707.16.06286-1

Copyright © 2016 EDIZIONI MINERVA MEDICA

lingua: Inglese

Lifelong amateur endurance practice attenuates oxidative stress and prevents muscle wasting in senior adults

Yaira, BARRANCO-RUIZ 1, 2, Jerónimo ARAGÓN-VELA 2, Cristina CASALS 2, Antonio MARTÍNEZ-AMAT 3, Emilio VILLA-GONZÁLEZ 1, Jesús R. HUERTAS 2

1 Department of Physical Culture, Faculty of Health Sciences, National University of Chimborazo, Riobamba, Ecuador; 2 Department of Physiology, Biomedical Research Centre, Faculty of Sport Sciences, Institute of Nutrition and Food Technology, University of Granada, Granada, Spain; 3 Department of Health Sciences, Faculty of Health Sciences, University of Jaén, Jaén, Spain


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BACKGROUND: The aim of the study was to investigate oxidative stress, muscle damage, enzymatic antioxidant defense and body composition in senior adults who have performed different lifelong physical activity practices.
METHODS: Twenty-three healthy senior men (60±1.88 years old) were divided into three groups according to their lifelong physical activity practice as follows: A) sedentary (N.=7); B) recreational (N.=9); and C) amateur (N.=7). Blood sampling was performed at rest to analyze plasma malondialdehyde (MDA) by TBARs-assay, nuclear DNA-damage in peripheral lymphocytes using Comet-Assay, the plasma enzymatic activity of glutathione peroxidase by spectrophotometry and serum alpha-actin release as skeletal muscle damage marker through western blot. Body composition was evaluated using anthropometric assessments by the ISAK protocol through skinfold thickness.
RESULTS: The lowest value of MDA was shown in the amateur group. Nuclear DNA-damage was significantly lower in the recreational group than in sedentary and amateur groups (MD=5.53±1.70; P=0.013. MD=5.61±1.62; P=0.008), respectively. The amateur group showed trends toward higher glutathione peroxidase enzymatic activity than recreational and sedentary groups. Alpha-actin levels were significantly higher in the amateur compared with recreational (MD=4.34±0.46; P<0.001) and sedentary groups (MD=4.89±0.46; P<0.001). The sedentary group showed significantly lower muscle mass (MD=3.67±1.10; P=0.011) and higher fat mass (MD=4.19±0.98; P=0.001) than amateur group.
CONCLUSIONS: The results described above suggest that the lifelong amateur endurance practice seems to improve oxidative stress response and strengthens hypertrophy mechanisms that might preserve muscle mass in senior adults.


KEY WORDS: Exercise - Oxidative stress - Physical endurance

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Publication History

Issue published online: March 23, 2017
Article first published online: April 5, 2016
Manuscript accepted: March 25, 2016
Manuscript revised: March 4, 2016
Manuscript received: November 12, 2015

Per citare questo articolo

Barranco-Ruiz Y, Aragón-Vela J, Casals C, Martínez-Amat A, Villa-González E, Huertas JR. Lifelong amateur endurance practice attenuates oxidative stress and prevents muscle wasting in senior adults. J Sports Med Phys Fitness 2017;57:670-7. DOI: 10.23736/S0022-4707.16.06286-1

Corresponding author e-mail

jeroav@ugr.es