Home > Riviste > The Journal of Sports Medicine and Physical Fitness > Fascicoli precedenti > The Journal of Sports Medicine and Physical Fitness 2016 December;56(12) > The Journal of Sports Medicine and Physical Fitness 2016 December;56(12):1574-82

ULTIMO FASCICOLO
 

JOURNAL TOOLS

eTOC
Per abbonarsi
Sottometti un articolo
Segnala alla tua biblioteca
 

ARTICLE TOOLS

Publication history
Estratti
Permessi
Per citare questo articolo

 

ORIGINAL ARTICLE  SPORT CARDIOLOGY 

The Journal of Sports Medicine and Physical Fitness 2016 December;56(12):1574-82

Copyright © 2016 EDIZIONI MINERVA MEDICA

lingua: Inglese

The impact of acute bouts of exercise on circulating cardiac natriuretic peptide and left ventricular function in untrained healthy young subjects

Hack L. KIM 1, 2, You N. KIM 2, Seon K. LEE 2, Jae B. SEO 1, 2, Woo Y. CHUNG 1, 2, Sue SHIN 3, Sang H. KIM 1, 2, Jong H. YOON 3, Myung A. KIM 1, 2, Joo H. ZO 1, 2

1 Division of Cardiology, Department of Internal Medicine, Seoul National University College of Medicine, Seoul, South Korea; 2 Cardiovascular Center, Seoul National University College of Medicine, Seoul, South Korea; 3 Department of Laboratory Medicine, Boramae Medical Center, Seoul National University College of Medicine, Seoul, South Korea


PDF


BACKGROUND: To examine the impact of a single bout of exercise on cardiac function and the blood level of brain natriuretic peptide (BNP) in healthy subjects.
METHODS: Thirty untrained, healthy young (aged between 20 and 29 years) volunteers (15 men and 15 women) were prospectively recruited. The plasma N-terminal pro-B-type BNP (NT-proBNP) level was checked, cardiac function was assessed using echocardiography in baseline conditions, and the values were compared with those obtained after treadmill exercise according to the Bruce protocol.
RESULTS: Left ventricular (LV) ejection fraction decreased after exercise in men, but not in women. Parameters of LV diastolic function were likely to change unfavorably in both sexes after exercise. NT-proBNP levels were significantly elevated by exercise in both sexes (from 22.1±18.3 to 24.7±20.2 pg/mL, P=0.006 in men; from 41.1±21.5 to 46.5±24.9 pg/mL, P<0.001 in women). Changes in NT-proBNP levels were significantly associated with those in E wave velocity, E wave deceleration time, E/e’ and E/propagation velocity (Vp) in men (P<0.05 for each) even after controlling for the effects of blood pressure and heart rate. In women, there were no significant associations between changes in parameters of LV diastolic function and those in NT-proBNP levels.
CONCLUSIONS: LV systolic and diastolic functions may deteriorate, and proBNP levels could be elevated even by a single bout of treadmill exercise in untrained young subjects. Dynamic change in LV diastolic function is a major stimulus to NT-proBNP release following exercise in men but not in women.


KEY WORDS: Brain natriuretic peptide - Diastole - Exercise - Sex

inizio pagina