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Original articles  IMMUNOLOGY 

The Journal of Sports Medicine and Physical Fitness 2003 March;43(1):99-104

Copyright © 2009 EDIZIONI MINERVA MEDICA

lingua: Inglese

Modulation of immune responses by treadmill exercise in Sprague-Dawley rats

Kim H. 1, Shin M. S. 1, Kim S. S. 1, Lim B. V. 2, Kim H. B. 2, Kim Y. P. 2, Chung J. H. 2, Kim E. H. 3, Kim C. J. 2

1 Research Institute of Sports Science Korea University, Seoul, Korea 2 Kohwang Medical Research Institute College of Medicine, Kyung Hee University, Seoul, Korea 3 Department of Meridianology, College of Oriental Medicine Semyung University, Chungbuk Korea


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Aim. The dura­tion-depen­dence of the ­effect of ­forced tread­mill exer­cise on the ­immune ­system is a sub­ject of ­ongoing ­research. In ­this ­study, the ­effect of ­forced tread­mill exer­cise on ­immune ­responses was inves­ti­gated by eval­u­ating the lym­pho­cyte ­subset frac­tions in the periph­eral ­blood and ­spleen of ­Sprague-­Dawley ­rats.
­Methods. Experi­mental ­design: Com­par­a­tive inves­ti­ga­tion ­over 8 ­weeks. Set­ting: Experi­mental ­animal labor­a­tory. Par­tic­i­pants: ­Male ­Sprague-­Dawley ­rats 5 ­weeks of age, ­weighing 150±10 g. Inter­ven­tions: Ani­mals ­were ran­domly ­assigned to one of the 4 fol­lowing ­groups: the con­trol ­group, the 1-­week-exer­cise ­group, the 4-­week-exer­cise ­group, and the 8-­week-exer­cise ­group. Meas­ures: Lym­pho­cyte ­subset frac­tions, ­including ­those for T, B, CD4+, and CD8+ ­cells and the T/B and CD4+/CD8+ ­ratios in the periph­eral ­blood and ­spleen ­were meas­ured via ­flow cyto­metric anal­ysis ­after tread­mill exer­cise.
­Results. The T ­cell and CD4+ ­cell frac­tions in ­both the periph­eral ­blood and ­spleen ­were ­increased sig­nif­i­cantly ­after 8 ­weeks of tread­mill exer­cise, but the B ­cell and CD8+ ­cell frac­tions did not ­change sig­nif­i­cantly.
Con­clu­sion. ­From the ­results of the ­present ­study, it is sug­gested ­that a ­period of one ­week is insuf­fi­cient to elim­i­nate the ­effects of exer­cise-­induced ­stress, ­that 4 ­weeks are ­needed to ­return to the con­trol ­state, and ­that at ­least 8 ­weeks are ­needed in ­order for exer­cise of mod­erate inten­sity to ­have a pos­i­tive ­effect on the ­immune ­system.

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