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Original articles   

The Journal of Sports Medicine and Physical Fitness 2001 March;41(1):11-7


lingua: Inglese

18F-FDG PET mapping of regional brain activity in runners

Tashiro M. 1, 3, Itoh M. 1, Fujimoto T. 2, Fujiwara T. 1, Ota H. 1, Kubota K. 5, Higuchi M. 3, Okamura N. 3, Ishii K. 4, Bereczki D. 6, Sasaki H. 3

From the 1 Division of Nuclear Medicine Cyclotron and Radioisotope Center 2 Department of Medicine and Science in Sports and Exercise, School of Medicine 3 Department of Gerontology and Respiratory Medicine School of Medicine 4 Division of Nuclear Engineering Faculty of Engineering, Tohoku University 5 Department of Nuclear Medicine and Radiology Tohoku University, Sendai, Miyagi, Japan 6 Department of Neurology University Medical School of Debrecen, Debrecen, Hungary


Background. To exam­ine region­al meta­bol­ic chang­es in the ­human ­brain ­induced by ­free run­ning in ­upright pos­ture.
Methods. Experimental ­design: region­al ­brain chang­es in glu­cose ­uptake ­induced by run­ning ­were exam­ined by com­par­ing ­brain imag­es ­obtained by posi­tron emis­sion tomog­ra­phy (PET) and 18F-flu­o­rod­e­ox­y­glu­cose (FDG). Setting: the ­study was con­duct­ed at a ­research insti­tute and ­involved par­tic­i­pa­tion of ­healthy ­young vol­un­teers. Data sam­pling and anal­y­sis ­required spe­cial imag­ing ­device and spe­cial com­put­er hard­ware/soft­ware. Participants: sub­jects ­were 17 ­healthy ­male vol­un­teers. They ­were divid­ed at ran­dom ­into two ­equal ­groups, ­those who ran 4-5 km and the oth­ers sat in the ­room. Measures: dif­fer­enc­es in region­al cere­bral glu­cose ­uptake ­between run­ners and con­trol ­groups ­were ­assessed sta­tis­ti­cal­ly. Plasma glu­cose lev­el was ­also meas­ured and glo­bal cere­bral ­uptake was esti­mat­ed.
Results. Running was asso­ciat­ed ­with a rel­a­tive ­increase of glu­cose ­uptake in the tem­po­rop­a­rie­tal asso­ci­a­tion cor­tex, occip­i­tal cor­tex, pre­mo­tor cor­tex and the cer­e­bel­lar ver­mis. The high­est activ­ity was not­ed in the tem­po­rop­a­rie­tal asso­ci­a­tion cor­tex. Activity of the pri­mary sen­sor­i­mo­tor cor­tex was high­er in the super­ome­di­al ­part (leg ­motor ­area) ­than the lat­er­al ­part (tho­rax and arm).
Conclusions. Running aug­ment­ed ener­gy con­sump­tion in the parie­to-occip­i­tal ­region rel­a­tive to the ­motor ­area, prob­ably due to the high­er ener­gy con­sump­tion nec­es­sary for inte­gra­tion of mul­ti­mod­al sen­so­ry infor­ma­tion ­than for gen­er­a­tion of ­motor out­put. Our ­results indi­cate ­that FDG PET is a use­ful ­tool for ­brain map­ping ­under var­i­ous phys­io­log­i­cal con­di­tions.

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