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The Journal of Sports Medicine and Physical Fitness 1999 December;39(4):275-81

Copyright © 2000 EDIZIONI MINERVA MEDICA

lingua: Inglese

Relationship between moderate intensity endurance training volume and natural killer cell cytolytic activity

Lee E. G. 1, Fox M. E. 1, Meadows G. G. 2, Johnson E. C. 1, Blank S. E. 1

1 Department of Kinesiology and Leisure Studies, Washington State University, Pullman, WA, USA; 2 Department of Pharmaceutical Sciences, Washington State University, Pullman, WA, USA


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Background. This ­study was ­designed to exam­ine the rela­tion­ship ­between endu­rance train­ing vol­ume and nat­u­ral kill­er ­cell (NK) cyto­lyt­ic activ­ity. We hypoth­e­sized ­that a ­dose depen­dent rela­tion­ship ­exists ­between ­forced tread­mill train­ing vol­ume and train­ing ­induced increas­es in NK ­cell cyto­lyt­ic activ­ity.
Methods. Experimental ­design: ­female, Swiss Webster ­mice ­were ­assigned to tread­mill con­trol (TC) or tread­mill ­trained ­groups (n=10 per ­group). Trained ­mice ran at 12 m per min. (8˚ ­grade) for: 15 (EX15), 30 (EX30), or 60 min­utes (EX60) per day, ­five ­days per ­week for 11 ­weeks. Splenic NK ­cell activ­ity was ­expressed as ­median lyt­ic ­unit (LU), ­median LU per asia­lo GM1 (AsGM1+) ­cell, and ­median LU per ­spleen.
Results. Median NK activ­ity was not sig­nif­i­cant­ly ­increased by train­ing vol­ume. A ­trend ­toward great­er ­median LU per AsGM1+ ­cell was ­observed in EX30 ­group ver­sus TC (p=0.1). Training vol­umes ­less ­than or great­er ­than ­this lev­el pro­duced small­er increas­es in NK cyto­lyt­ic activ­ity.
Conclusions. These ­data pro­vide pre­lim­i­nary evi­dence indi­cat­ing ­that train­ing ­induced increas­es in splen­ic NK ­cell cyto­lyt­ic activ­ity do not exhib­it a ­dose depen­dent rela­tion­ship ­with tread­mill train­ing vol­ume.

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