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Panminerva Medica 2022 Feb 22

DOI: 10.23736/S0031-0808.22.04641-9

Copyright © 2022 EDIZIONI MINERVA MEDICA

lingua: Inglese

Metabolic syndrome and bladder cancer

Marialaura RIGHETTO 1 , Daniele MODONUTTI 1, Francesco G. CELSO 1, Vittorio FULCOLI 2, Mariangela MANCINI 1

1 Department of Surgery, Urological Clinic, AULSS 6 Euganea, Camposampiero, Padova, Italy; 2 Department of Surgery, Oncology, and Gastroenterology, Urological Clinic, University of Padova, Padova, Italy


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Metabolic syndrome (MetS) is a widely diffused dysmetabolism, well known to be associated with an increased cardiovascular risk. However, a growing burden of evidence links MetS with several malignancies, potentially influencing the onset, progression, and therapeutic response. In this work, we critically explored the relationship between MetS and bladder cancer through a narrative review, researching the most recent literature on the topic using PubMed, MEDLINE, and EMBASE. We found that the current evidence on the subject is heterogeneous and inconsistent, making it difficult to draw definitive conclusions. Furthermore, since MetS would be a modifiable oncological risk factor, more high-quality data is needed for tailored treatment of bladder cancer.


KEY WORDS: Bladder cancer; Metabolic syndrome; Hypertension; Obesity; Diabetes mellitus

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