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Panminerva Medica 2021 Jul 26

DOI: 10.23736/S0031-0808.21.04500-6

Copyright © 2021 EDIZIONI MINERVA MEDICA

lingua: Inglese

Helicobacter pylori eradication with a clarithromycin-based triple therapy in elderly patients: a case-control study

Marilena DURAZZO 1, 2 , Arianna FERRO 1, Sharmila FAGOONEE 3, Maria T. STAIANO 1, 4, Giorgio M. SARACCO 1, 4, Rinaldo PELLICANO 4

1 Department of Medical Sciences, University of Turin, Turin, Italy; 2 Section of Geriatrics, Department of Medical Sciences, University of Turin, Turin, Italy; 3 Institute for Biostructure and Bioimaging, National Research Council, Molecular Biotechnology Centre, Turin, Italy; 4 Unit of Gastroenterology, Città della Salute e della Scienza-Molinette Hospital, Turin, Italy


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BACKGROUND: Helicobacter pylori (H. pylori), main agents of several gastroduodenal diseases, represents a therapeutic challenge. Since the influence of age on the success of bacterial treatment remains uncertain, in this case-control study we assessed the efficacy of a standard H. pylori eradication therapy among elderly patients.
METHODS: In this retrospective study, a total of 361 naïve patients (194 males, mean age 79.8± 3.4 years) aged more than 65 years and treated with a triple therapy regimen comprising a standard dose of omeprazole twice daily, amoxicillin 1g twice daily and clarithromycin 500 mg twice daily, for 7, 10 or 14 days, were included. They were compared with naïve patients, younger than 65 years (mean age 43± 2.7 years). Since in the year 2017, we began to use the three-in-one single capsule bismuth-containing quadruple therapy, the search was ended at 31 December 2016.
RESULTS: Overall, H. pylori eradication rate in the intention-to-treat (ITT) analysis, was 70.9% (256/361) among elderly patients versus 70.9% (256/361) among young patients. Dividing by treatment duration, among elderly patients, eradication was obtained in 78.1% (50/64), 69.1% (139/201) and 69.7% (67/96) elderly patients within 7-day, 10-day and 14-day regimens, respectively, without statistical difference. Out of 361 elderly patients, 11 were excluded from the per protocol (PP) analysis because of discontinuations (7 for adverse events). One subject discontinued treatment among young patients. Also the PP analysis showed no statistical difference, with an eradication rate of 73.1% (256/350) among elderly patients versus 71.1% (256/360) among young patients.
CONCLUSIONS: Elderly does not affect efficacy or safety of a clarithromycin-based triple therapy for H. pylori eradication.


KEY WORDS: Helicobacter pylori; Elderly; Disease eradication; Antibiotics

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