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Panminerva Medica 2021 Feb 02

DOI: 10.23736/S0031-0808.21.04303-2


lingua: Inglese

The core components of cardio-oncology rehabilitation

Elio VENTURINI 1 , Susan GILCHRIST 2, Elisabetta CORSI 3, Anna DI LORENZO 4, Gianluigi CUOMO 4, Giuseppe D’AMBROSIO 4, Mario PACILEO 5, Antonello D’ANDREA 5, Maria Laura CANALE 6, Gabriella IANNUZZO 7, Filippo M. SARULLO 8, Carlo VIGORITO 4, Sandro BARNI 9, Francesco GIALLAURIA 4, 10

1 Cardiac Rehabilitation Unit, Azienda USL Toscana Nord-Ovest, Cecina Civil Hospital, Cecina, Livorno, Italy; 2 Department of Clinical Cancer Prevention, Department of Cardiology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA; 3 Department of Cardiology, Azienda USL Toscana Nord-Ovest, Cecina, Civil Hospital, Cecina, Livorno, Italy; 4 Department of Translational Medical Sciences, Division of Internal Medicine and Cardiac Rehabilitation, Federico II University of Naples, Naples, Italy; 5 Unit of Cardiology and Intensive Care, Umberto I Hospital, Nocera Inferiore, Salerno, Italy; 6 Department of Cardiology, Azienda USL Toscana Nord-Ovest, Versilia Hospital, Lido di Camaiore, Lucca, Italy; 7 Department of Clinical Medicine and Surgery, Federico II University, Naples, Italy; 8 Cardiovascular Rehabilitation Unit, Buccheri La Ferla Fatebenefratelli Hospital, Palermo, Italy; 9 Azienda Socio-Sanitaria Territoriale di Bergamo Ovest, Bergamo, Italy; 10 Faculty of Sciences and Technology, University of New England, NSW Australia


The increased efficacy of cancer therapy has resulted in greater cancer survival and increasing number of people with cancer and cardiovascular disease. The sharing of risk factors, the bidirectional relationship between cancer and cardiovascular diseases and the cardiotoxic effect of chemotherapy and radiotherapy, are the cause of the rapid expansion of Cardio-oncology. All strategies to preserve cardiovascular health and mitigate the negative effect of cancer therapy, by reducing the cardiovascular risk, must be pursued to enable the timely and complete delivery of anticancer therapy and to achieve the longest remission of the disease. Comprehensive cardiac rehabilitation is an easy-to-use model, even in cancer care, and is the basis of Cardio-Oncology REhabilitation (CORE), an exercise-based multicomponent intervention. In addition, CORE, besides using the rationale and knowledge of cardiac rehabilitation, can leverage the network of cardiac rehabilitation services to offer to cancer patients exercise programs, control of risk factors, psychological support and nutrition counseling. The core components of CORE will be discussed, describing the beneficial effect on cardiorespiratory fitness, quality of life, psychological and physical well-being and weight management. Furthermore, particular attention will be paid to how CORE can counterbalance the negative effect of therapies in those at heightened cardiovascular risk after a cancer diagnosis. Barriers to implementation, including personal, family, social and of the health care system barriers for a widespread diffusion of the CORE will also be discussed. Finally, there will be a call-to-action, for randomized clinical trials that can test the impact of CORE, on morbidity and mortality.

KEY WORDS: Cardio-oncology rehabilitation core components; Exercise in cancer; Shared risk factor between cancer/cardiovascular disease; Bidirectional relationship cancer/cardiovascular disease

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