Home > Riviste > Panminerva Medica > Fascicoli precedenti > Articles online first > Panminerva Medica 2018 Feb 13



Publication history
Per citare questo articolo


Rivista di Medicina Interna

Indexed/Abstracted in: BIOSIS Previews, Current Contents/Clinical Medicine, EMBASE, PubMed/MEDLINE, Science Citation Index Expanded (SciSearch), Scopus
Impact Factor 1,698



Panminerva Medica 2018 Feb 13

DOI: 10.23736/S0031-0808.18.03416-X


lingua: Inglese

Quantification of ultrasound imaging in the staging of hepatic fibrosis

Paolo BORRO 1 , Silvana G. DELLEPIANE 2, Rinaldo PELLICANO 3, Laura GEMME 2, Sharmila FAGOONEE 4, Gianni TESTINO 5

1 Gastroenterology Unit, Ospedale Policlinico San Martino, Department of Internal Medicine, Genova, Italy; 2 Department of Electrical, Electronic, Telecommunications Eng. and Naval Architecture (DITEN), University of Genova, Genova, Italy; 3 Unit of Gastroenterology, Molinette Hospital, Torino, Italy; 4 Institute for Biostructures and Bioimages (CNR) c/o Molecular Biotechnology Center, Turin, Italy; 5 Alcohological Regional Center, Ligurian Region, ASL3 Genovese, Genova, Italy


OBJECTIVE: The need for a staging of hepatic fibrosis has become particularly urgent in the last few years in order to start new therapeutic treatments. The objective of this study is to identify ultrasound descriptors and achieve a staging of hepatic fibrosis with non-invasive, rapid and inexpensive methods, both as an alternative and a support to the ultrasound elastography examination.
MATERIALS AND METHODS: This study evaluated 196 patients under treatment at the Alcohological Regional Center. An image regarding a scanning of the epigastrium with a high-frequency linear probe (7,5-12 MHz) has been selected for quantification. The hyperechogenic line corresponding to the Glisson capsule on the hepatic segment III has been evaluated with the GLQ (Genoa Line Quantification) software. These data have been compared with the shearwave ultrasound elastography.
RESULTS: The best discrimination between patients with medium-advanced fibrosis (F3-F4) and healthy patients or patients with no fibrosis or mild fibrosis (F0-F1) has been achieved using the three parameters of variance and mean of gradient and line continuity. In particular, a sensitivity of 74%, a specificity of 82%, PPV 80.4%, NPV 75.9% and an accuracy of 78% have been obtained.
CONCLUSIONS: GQL has allowed a classification, which is well concordant with the ultrasound elastography data. The use of the GQL may also be developed within centers, which are not provided with ultrasound elastography techniques, when an ultrasound elastography examination cannot be performed due to technical problems and as a support to elastography, if the outcome of this examination is not sufficiently clear.

KEY WORDS: Hepatic fibrosis - Shearwave elastography - Ultrasound - Cirrhosis - Alcohol - Quantification

inizio pagina

Publication History

Article first published online: February 13, 2018
Manuscript accepted: February 8, 2018
Manuscript received: January 27, 2018

Per citare questo articolo

Borro P, Dellepiane SG, Pellicano R, Gemme L, Fagoonee S, Testino G. Quantification of ultrasound imaging in the staging of hepatic fibrosis. Panminerva Med 2018 Feb 13. DOI: 10.23736/S0031-0808.18.03416-X

Corresponding author e-mail