Home > Riviste > Panminerva Medica > Fascicoli precedenti > Panminerva Medica 2020 September;62(3) > Panminerva Medica 2020 September;62(3):164-75

ULTIMO FASCICOLO
 

JOURNAL TOOLS

Opzioni di pubblicazione
eTOC
Per abbonarsi
Sottometti un articolo
Segnala alla tua biblioteca
 

ARTICLE TOOLS

Publication history
Estratti
Permessi
Per citare questo articolo
Share

 

REVIEW   

Panminerva Medica 2020 September;62(3):164-75

DOI: 10.23736/S0031-0808.20.03904-X

Copyright © 2020 EDIZIONI MINERVA MEDICA

lingua: Inglese

Beyond the growth delay in children with sleep-related breathing disorders: a systematic review

Marco ZAFFANELLO 1 , Giorgio PIACENTINI 1, Stefania LA GRUTTA 2

1 Department of Surgical Sciences, Dentistry, Gynecology and Pediatrics, University of Verona, Verona, Italy; 2 National Research Council of Italy, Institute for Research and Biomedical Innovation, Palermo, Italy



INTRODUCTION: The availability of high-quality studies on the association between sleep-disordered breathing in children and delayed growth associated with the hormonal profile recorded before surgery and at follow-up is limited.
EVIDENCE ACQUISITION: Medline PubMed, Scopus and WebOfScience databases were searched for relevant publications published between January 2008 to January 2020 and a total of 261 potentially eligible studies were identified.
EVIDENCE SYNTHESIS: Following review 19 papers were eligible for inclusion: seven reported a significant postsurgical increase in growth regardless of initial weight status, type of surgery, type of study design, and length of follow-up period. The only high-quality study was a randomized controlled trial that found an increased risk of obstructive sleep apnea syndrome relapse in overweight children. Twelve studies reported the significant increase in growth parameters showing that IGF-1, IGFBP-3, and ghrelin may boost growth after surgery.
CONCLUSIONS: The current systematic review demonstrates a scarcity of high-quality studies on growth delay in children with sleep-disordered breathing. Significant catch-up growth after surgery in the short term and changes in IGF-1, IGFBP-3, ghrelin, and leptin levels has been reported in most published studies.


KEY WORDS: Adenoidectomy; Tonsillectomy; Failure to thrive; Biomarkers; Sleep apnea, obstructive

inizio pagina