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Panminerva Medica 2018 June;60(2):60-4

DOI: 10.23736/S0031-0808.18.03420-1

Copyright © 2018 EDIZIONI MINERVA MEDICA

lingua: Inglese

Temporary kidney dysfunction: Robuvit® supplementation in initial, transient kidney insufficiency and micro-macro albuminuria

Andrea LEDDA 1, 2, Gianni BELCARO 1, 2 , Beatrice FERAGALLI 1, 2, Morio HOSOI 1, 2, Marisa CACCHIO 1, 2, Roberta LUZZI 1, 2, Mark DUGALL 1, 2, Roberto COTELLESE 1, 2, Maria R. CESARONE 1, 2

1 IRVINE3 Labs, Chieti-Pescara University, Chieti, Italy; 2 International Agency for Pharma Standard Supplements (IAPPS), Chieti, Italy


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BACKGROUND: The aim of this study was to evaluate the efficacy of Robuvit® (French oak extract, Horphag Research) in improving kidney function in subjects with temporary kidney dysfunction (TKD) and increased oxidative stress levels.
METHODS: Fifty-seven subjects with TKD were included in the registry. Subjects were divided into two goups according to albumin levels in the urine. Plasma free radicals were measured in order to evaluate a possible connection with alterations in kidney function. Robuvit® was used at the dose of three capsules/day (300 mg/day) for 4 weeks.
RESULTS: Subjects with micro-albuminuria treated with Robuvit® improved significantly more than controls treated with standard management, achieving a full normalization of albumin levels in the urine (P<0.05). In subjects with macroalbuminuria, the decrease in albumin loss was also significant after four weeks, with better overall results in Robuvit® supplemented patients (P<0.05) than in controls.
CONCLUSIONS: Albuminuria, as a significant marker of TKD, can be significantly and safely improved with Robuvit® supplementation.


KEY WORDS: Renal Insufficiency - Albuminuria - Robuvit

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