REVIEW   

Panminerva Medica 2018 March;60(1):25-8

DOI: 10.23736/S0031-0808.17.03382-1

Copyright © 2017 EDIZIONI MINERVA MEDICA

lingua: Inglese

Role of microRNAs (miRNAs) in the pathophysiology of diabetes mellitus

Juhi TIWARI ¹, Gaurav GUPTA ¹ ✉, Terezinha de JESUS ANDREOLI PINTO ², Rahul SHARMA ¹, Kavita PABREJA ³, Yogesh MATTA ¹, Neha ARORA ¹, Anurag MISHRA ⁴, Rakesh SHARMA ⁴, Kamal DUA ^{5, 6}

¹ School of Pharmaceutical Sciences, Jaipur National University, Jagatpura, Jaipur, India; ² Department of Pharmacy, Faculty of Pharmaceutical Sciences, University of São Paulo, São Paulo, Brazil; ³ School of Medicine and Public Health, University of Newcastle, Newcastle, Australia; ⁴ School of Pharmacy, Suresh Gyan Vihar University, Jaipur, India; ⁵ Discipline of Pharmacy, Graduate School of Health, University of Technology Sydney, Ultimo, Australia; ⁶ School of Pharmaceutical Sciences, Shoolini University, Solan, India

Diabetes mellitus is becoming the critical problem among the entire world and it is difficult to understand the molecular mechanism representing the concept of diabetic pathology. Recently the knowledge of the involvement of genetics in type 2 diabetes mellitus (T2DM) susceptibility has sketched a great concentration towards the transcriptional activity of β cells within the pancreas. This disease becomes the leading cause of death, so it is necessary to study the molecular pathogenesis, phenotypes, and characteristics to design the therapeutic parameters. Here in this review role of miRNA is being illustrated as it plays a crucial role in the pathogenesis, progression, and fate of beta cells of pancreas regulating the insulin secretion. Here in this review, we try to include the effects and pathophysiology of various miRNA in diabetes mellitus and on the various sites of the human body.

KEY WORDS: MicroRNAs - Diabetes mellitus - Insulin - Physiopathology - Cell differentiation - Cell proliferation