TARGETING CARDIAC ISSUES 

Panminerva Medica 2015 March;57(1):1-13

Copyright © 2015 EDIZIONI MINERVA MEDICA

lingua: Inglese

Bioresorbable scaffolds: focus on vascular response and long-term safety

Scalone G., Brugaletta S., Gomez O., Otsuki S., Sabate M. ✉

Thorax Institute, Department of Cardiology, IDIBAPS: Institut d’Investigacions Biomediques Agust Pi i Sunyer (IDIBAPS), Hospital Clinic, Barcelona, Spain

Bioresorbable vascular scaffolds (BVS) are considered the fourth revolution in Interventional Cardiology, thus promising to address some of the pending issues with current-generation drug eluting stents (DES). Notably, most of the potential advantages of BVS over other current devices are due to a peculiar vascular response, called “vascular restoration therapy”. The emerging data from real-world expanded use registries suggest that BVS use is feasible in a wide variety of patients (from low- to high- risk), and lesions (from simplex to complex). However, few safety concerns with currently available BVS have arised from initial experiences all over the word. Data from ongoing large-scale randomized controlled trials will be able to demonstrate whether BVS improve patient early and long-term outcomes compared to best-in-class DES.