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CASE REPORTS
Panminerva Medica 2002 June;44(2):149-50
Copyright © 2009 EDIZIONI MINERVA MEDICA
lingua: Inglese
A case of Sweet’s syndrome associated with monoclonal immunoglobulin of IgG-lambada type and p-ANCA positivity
Nocente R., Cammarota G. *, Gentiloni Silveri N. *, Rotoli M. **, Zannoni G. F. ***, Bertazzoni G., Ceccanti M. ****, Gasbarrini G. *
From the Emergency Department and ****Institute of Sixth Medical Clinic, Rome University “La Sapienza”, Rome, Italy *Department of Internal Medicine **Department of Dermatology ***Department of Pathology Catholic University of Rome, Rome, Italy
We report a case of Sweet’s syndrome associated with monoclonal gammopathy of uncertain significance (MGUS) and positivity for perinuclear antineutrophil cytoplasmic antibodies (p-ANCA). A 65-year-old man patient came to our hospital complaining of remittent-intermittent fever, weight loss, associated with papules affecting all his body and without mucosal or ocular involvement. Histology of biopsy specimens of papules allowed the diagnosis of Sweet’s syndrome. This is the first case of this rare syndrome associated both with MGUS and p-ANCA positivity. The monoclonal immunoglobulin, possibly directed to neutrophils like an antibody, may cause both their fragmentation and release of antigens responsible of p-ANCA appearance.