ORIGINAL ARTICLES   

Panminerva Medica 2000 September;42(3):179-82

Copyright © 2009 EDIZIONI MINERVA MEDICA

lingua: Inglese

Role of monocytes in the early phase of acute myocardial infarction

Aliberti G., Pulignano I., Proietta M., De Michele L. V., Corvisieri P., Minisola S.

From the Clinica Medica II Università degli Studi «La Sapienza», Roma, Italy

Background. In ­acute myo­car­dial infarc­tion periph­er­al leu­co­cy­to­sis ­occurs ear­ly and fibrino­gen lev­els ­increase in ­response to the tis­sue inju­ry, ­expressed by the ­enhanced enzym­e plas­ma lev­els. The aim of the ­present ­study has ­been to inves­ti­gate if a uni­fy­ing ­link ­between ­these mod­ifi­ca­tions ­might be ­found.
Methods. In 325 ­patients, 246 men and 79 wom­en, 61.46±11.00 and 70.03±11.30 ­years ­mean age respec­tive­ly, at admis­sion for myo­car­dial infarc­tion and ­before treat­ment, we simul­ta­ne­ous­ly meas­ured plas­ma fibrino­gen (FBG), hemo­chro­mo­cy­to­met­ric parem­e­ters and plas­ma ­enzyme aspar­tate and ala­nine trans­am­i­nase (AST and ALT), lac­tate dehy­drog­e­nase (LDH) and crea­tine phos­phok­i­nase (CPK). The sta­tis­ti­cal anal­y­sis was per­formed by ­using stan­dard mul­ti­ple regres­sion for depen­dent var­i­able FBG and for the var­i­ables ­white ­blood ­cells (WBC), mono­cyte num­ber, ­large ­unstained ­cells (LUC) and CPK.
Results. The ­results ­showed ­that FBG was sig­nif­i­cant­ly cor­re­lat­ed ­with mono­cyte (p<0.001) and LUC (p<0.05) ­counts; ­assumed as depen­dent var­i­able, fur­ther on ­with FBG, mono­cyte num­ber was cor­re­lat­ed ­with WBC ­count, LUC and CPK; fur­ther on ­with mono­cyte num­ber, WBC ­with neu­tro­phile and lym­pho­cyte ­counts, LUC ­with CPK, CPK ­with LDH.
Conclusions. The study seems to show that monocyte modifications occur already in the early phase of myocardial infarction. These mod­ifi­ca­tions are direct­ly relat­ed to dam­age exten­sion, as dedu­cible ­from CPK lev­els, and ­seem to main­ly mod­ulate FBG and WBC, ­since the cyto­kines and hemat­o­poiet­ic ­growth fac­tors pro­duc­tion by acti­vat­ed mono­cy­tes.