ORIGINAL ARTICLES   

Panminerva Medica 2000 March;42(1):11-5

Copyright © 2009 EDIZIONI MINERVA MEDICA

lingua: Inglese

ATP-MgCl2 treatment after experimental acute myocardial ischemia and reperfusion

Katircioglu S. F., Ulus A. T., Saritas Z.

From the Cardiovascular Surgery Department Türkiye Yüksek Ihtisas Hospital of Ankara *Veterinary Faculty of University of Ankara, Turkey

Back­ground. The ­effect of ATP-­MgCl2 on myo­car­dial metab­olism and hemo­dy­nam­ics was inves­ti­gat­ed in ­this ­study.
Meth­ods. ­Twelve ­dogs ­were ­entered in ­this ­research. Six ­dogs ­received ATP-­MgCl2 and the remain­ing ­dogs ­were con­sid­ered as con­trols. The ­amount of ATP and ­MgCl2 con­cen­tra­tion of ­this solu­tion is 100 µmol/ml ­each. The vol­ume admin­is­tered to the ani­mals dur­ing the aor­tic occlu­sion is 0.25 ml/kg/­hour; in the solu­tion are 100 µmol/ml ­dose ­each. The vol­ume admin­is­tered to the ani­mals dur­ing reper­fu­sion is 0.25 ml/kg/­hour. The ­left ante­ri­or descend­ing ­artery was occlud­ed for a peri­od of one ­hour and the ­drug was admin­is­tered dur­ing reper­fu­sion.
­Results. ­Three ­hours ­after reper­fu­sion, car­diac out­put was 1524±26 ml/min in the con­trol ­group and 1638±47 ml/min in the ATP-­MgCl2 ­group (p<0.05), pul­mo­nary cap­il­lary ­wedge pres­sure was 14±3 in the con­trol ­group and 8±2 in the ATP-­MgCl2 ­group. At the ­same ­time inter­val tis­sue ATP and lac­tate lev­el was 7±3, 1.3±0.4 in the con­trol ­group and 14±2, 0.0±0.2 in the ATP-­MgCl2 ­group respec­tive­ly (p<0.05).
Con­clu­sions. In ­this ­study we dem­on­strat­ed ­that ATP-­MgCl2 ­usage ­after one ­hour of arte­ri­al occlu­sion pro­tects the ­heart ­from the ­adverse ­effects of ische­mia/reper­fu­sion.