![]() |
JOURNAL TOOLS |
eTOC |
Per abbonarsi |
Sottometti un articolo |
Segnala alla tua biblioteca |
ARTICLE TOOLS |
Estratti |
Permessi |
Share |

I TUOI DATI
I TUOI ORDINI
CESTINO ACQUISTI
N. prodotti: 0
Totale ordine: € 0,00
COME ORDINARE
I TUOI ABBONAMENTI
I TUOI ARTICOLI
I TUOI EBOOK
COUPON
ACCESSIBILITÀ
ORIGINAL ARTICLES
Panminerva Medica 1998 September;40(3):196-8
Copyright © 2000 EDIZIONI MINERVA MEDICA
lingua: Inglese
Does endothelin-1 play a role in the renal function of cirrhotic patients?
Bruno C. M., D’Amico R., Ierna D., Neri S.
From the Institute of Internal and Emergency Medicine University of Catania, Catania, Italy
Methods. We investigated plasma and urinary endothelin-1 levels in eleven cirrhotic patients and ten healthy control subjects, to evaluate whether endothelin is involved in renal functional alterations of liver cirrhosis.
Results. No significant difference in plasma ET-1 levels was observed between the two groups (p>0.05) but urinary ET-1 excretion was significantly higher in cirrhotics than in controls (p<0.001). Creatinine clearance (mean 56±7.6 ml/min) showed an inverse correlation with plasma ET-1 levels (p<0.05) in cirrhotics.
Conclusions. We believe this may be caused by enhanced local ET-1 activity linked to an up-regulation of its specific receptors and/or increased renal synthesis, resulting in augmented urinary excretion.