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Panminerva Medica 1998 June;40(2):126-7

Copyright © 2000 EDIZIONI MINERVA MEDICA

lingua: Inglese

Bone density in women with endometriosis

Colacurci N., De Seta L., Passaro M., Scala P., De Franciscis P., Zarcone R.

From the Department of Gynecology and Obstetrics, School of Medicine, II University of Naples, Naples, Italy


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Objective. To eval­u­ate ­the ­impact of endo­me­tri­o­sis on ­bone metab­olism.
Materials ­and meth­ods. We com­pared ­bone min­er­al den­sity ­and bio­chem­i­cal ­markers (plas­ma oste­o­cal­cin, ­bone alka­line phos­pha­tase, fast­ing uri­nary hydrox­y­pro­line, uri­nary excre­tion of ­cross-­linked N-tel­o­pep­tide of ­type I col­la­gen) of ­bone turn­over in for­ty-­nine per­i­men­o­pau­sal wom­en under­go­ing lap­a­rot­o­my ­because of ­benign gyne­co­log­ic pathol­o­gy: in twen­ty-­four of ­them (­group A) endo­me­tri­o­sis ­was diag­nosed, ­the remain­ing twen­ty-­five rep­re­sent­ed ­the con­trol ­group (group B). Statistical anal­y­sis ­was per­fomed by ­means of Student “t”-­test; sig­nif­i­cance ­was ­set at p<0.05.
Results. Bone den­sity of ­the lum­bar ­spine (0.898±0.325 vs 0.940±0.350) ­and ­bone mark­ers ­failed to ­show sta­tis­ti­cal­ly sig­nif­i­cant dif­fer­enc­es ­between ­the ­two ­groups. No sig­nif­i­cant cor­re­la­tion ­was ­observed ­between ­any ­bone den­sity meas­ure­ment ­and sever­ity of endo­me­tri­o­sis.
Conclusion. Endometriosis ­does ­not ­seem to ­induce ­even in ­advanced stag­es, a reduc­tion of ­bone den­sity.

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