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Panminerva Medica 1998 March;40(1):58-62

Copyright © 2000 EDIZIONI MINERVA MEDICA

lingua: Inglese

Physiopathology of the renin-angiotensin system in the ovary

De Nuccio I., Salvati G., Genovesi G., Paolini P., Marcellini L., Schiavello V., Re M.

From the Department of Medical Physiopathology Chair of Endocrine Physiopathology University of Rome “La Sapienza”, Rome, Italy


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The ­present ­review con­firms the exis­tence of the so-­called “ovar­ian-­derived pro­re­nin-angio­ten­sin cas­cade”. It also ­describes the phys­io­pa­thol­o­gy of the ­system and, con­se­quent­ly, its role in the gen­e­sis of phe­nom­e­na con­cern­ing repro­duc­tive func­tion such as ovu­la­tion, ster­oid syn­the­sis and fol­li­cu­lo­gen­e­sis. Moreover, the “ovar­ian-­derived pro­re­nin-angio­ten­sin cas­cade” ­appears to play an impor­tant role in the aetio­path­o­gen­e­sis of dis­eas­es such as ovar­ian ­tumours, ovar­ian hyper­stim­u­la­tion syn­drome and ectop­ic preg­nan­cy.

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