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OTORINOLARINGOLOGIA

Rivista di Otorinolaringologia, Chirurgia Maxillo-Facciale,
Chirurgia Plastica Ricostruttiva, Otoneurochirurgia


Indexed/Abstracted in: EMBASE, Scopus


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Otorinolaringologia 2017 June;67(2):61-7

DOI: 10.23736/S0392-6621.17.02103-8

Copyright © 2017 EDIZIONI MINERVA MEDICA

lingua: Inglese

Study of common mitochondrial mutations in patients with nonsyndromic hearing loss

Mohammadreza MAHMOUDIAN SANI 1, 2, Ameneh MEHRI-GHAHFARROKHI 3, Hamed AHMADI 4, Ali SHOJAEIAN 3, Morteza HASHEMZADEH-CHALESHTORI 3, Ali MAHDAVINEZHAD 1, 2, Massoud SAIDIJAM 1, 2

1 Research Center for Molecular Medicine, Hamadan University of Medical Sciences, Hamadan, Iran; 2 Department of Genetics and Molecular Medicine, Hamadan University of Medical Sciences, Hamadan, Iran; 3 Cellular and Molecular Research Center, Shahrekord University of Medical Sciences, Shahrekord, Iran; 4 Department of Psychology and Educational Sciences, School of Psychology, Allame Tabatabaei University, Tehran, Iran


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INTRODUCTION: Hearing loss is the most common sensorineural disorder involving one out of 1000 people. Around 50% of hearing losses occur due to genetic causes. Three mitochondrial mutations, A1555G in MTRNR1, A3243G in MTTL1, and A7445G in MTTS1, are the most important non-syndromic sensorineural causes of hearing loss in some populations. The aim of this review was to study common mitochondrial mutations in people with hearing loss in Iran.
EVIDENCE ACQUISITION: Directory of Open Access Journals (DOAJ), Google Scholar, PubMed (NLM), LISTA (EBSCO) and Web of Science were searched.
EVIDENCE SYNTHESIS: Studies have indicated that the mitochondrial mutations A3243G, A1555G, and A7445G play no significant part in the development of hearing loss in Iran. Different variants of A7445C and G3316A have been identified in Iran.
CONCLUSIONS: Further studies on other ethnicities and with a larger sample size are necessary to elucidate the role of these genes in hearing loss development in Iran.


KEY WORDS: Hearing loss - Mutation - Disease susceptibility

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Publication History

Issue published online: May 5, 2017
Manuscript accepted: January 17, 2017
Manuscript received: December 16, 2016

Per citare questo articolo

Mahmoudian Sani M, Mehri-Ghahfarrokhi A, Ahmadi H, Shojaeian A, Hashemzadeh-Chaleshtori M, Mahdavinezhad A, et al. Study of common mitochondrial mutations in patients with nonsyndromic hearing loss. Otorinolaringol 2017;67:61-7. DOI: 10.23736/S0392-6621.17.02103-8

Corresponding author e-mail

molecular_hearingloss10025@yahoo.com