Home > Riviste > The Quarterly Journal of Nuclear Medicine and Molecular Imaging > Fascicoli precedenti > Articles online first > The Quarterly Journal of Nuclear Medicine and Molecular Imaging 2022 Feb 04

ULTIMO FASCICOLO
 

JOURNAL TOOLS

Opzioni di pubblicazione
eTOC
Per abbonarsi
Sottometti un articolo
Segnala alla tua biblioteca
 

ARTICLE TOOLS

Publication history
Estratti
Permessi
Per citare questo articolo
Share

 

 

The Quarterly Journal of Nuclear Medicine and Molecular Imaging 2022 Feb 04

DOI: 10.23736/S1824-4785.22.03389-1

Copyright © 2022 EDIZIONI MINERVA MEDICA

lingua: Inglese

(11) C-Methionine Positron Emission Tomography/Magnetic Resonance Imaging in postoperative patients after craniotomy: Zero echo time and Head Atlas versus Computed Tomography based attenuation correction

Francesca DE LUCA 1, 2 , Martin BOLIN 1, 3, Lennart BLOMQVIST 3, 4, Cecilia WASSBERG 3, Heather MARTIN 2, Anna FALK DELGADO 1, 2

1 Department of Clinical Neuroscience, Karolinska Institutet, Solna, Sweden; 2 Department of Neuroradiology, Karolinska University Hospital, Stockholm, Sweden; 3 Department of Medical Radiation Physics and Nuclear Medicine, Karolinska University Hospital, Stockholm, Sweden; 4 Department of Molecular Medicine and Surgery Karolinska Institutet, Solna, Sweden



BACKGROUND: Attenuation correction (AC) is an important topic in PET/MRI and particularly challenging after brain tumour surgery, near metal implants, adjacent bone and burr holes. In this study, we evaluated the performance of two MR-driven AC methods, ZTE- and atlas-AC, in comparison to reference standard CT-AC in patients with surgically treated brain tumors at 11C-Methionine PET/MRI.
METHODS: This retrospective study investigated seven postoperative patients with neuropathologically confirmed brain tumour at 11C-Methionine PET/MRI. Three AC maps - ZTE-AC, atlas-AC and reference standard CT-AC - were generated for each patient. Standardised uptake values (SUV) were obtained at the metal implant, adjacent bone and burr hole. Standard uptake ratio (SUR) SURmetal/mirror, SURbone/mirror and SURburrhole/mirror were then calculated and analyzed with Bland-Altman, Pearson correlation and intraclass correlation reliability.
RESULTS: Smaller mean bias range % (Bland-Altman) was found for ZTE- than atlas-AC in all analyses (Metal ZTE -0.46 - -0.02, Metal atlas -3.57 - -3.26; Bone ZTE -4.60- -2.16, Bone atlas -5.25- -3.81; Burr hole ZTE -0.95- -0.52, Burr hole atlas 7.86-8.87). SD range % (Bland-Altman) was large for both methods in all analyses, with lower absolute values for ZTE-AC (ZTE 7.02-8.49; Atlas 11.47-14.83). A very strong correlation (Pearson correlation) was demonstrated for both methods compared to CT-AC (ZTE ρ 0.97-0.99, p <0.001; atlas ρ 0.88-0.91, p ≤0.009) with higher absolute values for ZTE. An excellent intraclass correlation
coefficient was found across all analyses for ZTE, atlas and CT maps (ICC ≥0.88).
CONCLUSIONS: ZTE for MR-driven PET attenuation correction presented a more comparable performance to reference standard CT-AC at the postoperative site. ZTE-AC may serve as a useful diagnostic tool for MR-driven AC in patients with surgically treated brain tumors.


KEY WORDS: Attenuation correction; PET/MRI; ZTE-AC; atlas-AC; CT-AC

inizio pagina