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The Quarterly Journal of Nuclear Medicine and Molecular Imaging 2021 Sep 03

DOI: 10.23736/S1824-4785.21.03357-4

Copyright © 2021 EDIZIONI MINERVA MEDICA

lingua: Inglese

Possibility analysis of thyroid imaging parameters for dose adjustment in 131I treatment of hyperthyroidism

Xiaonan ZHANG, Junhong LI, Hui ZHOU, Qiteng LU, Hailian WEI, Aifeng LI, Xinyu WEI, Zhixiao WEI

Department of Nuclear Medicine, the First Affiliated Hospital of Guangxi Medical University, Nanning, China


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BACKGROUND: To determine the thyroid uptake rate by correcting the background and analyse its clinical significance.
METHODS: The study included 161 patients with hyperthyroidism. The thyroid uptake rate was calculated by drawing a 100 pixels ROI (Region of Interest) background, above and below the thyroid and correcting the thyroid ROI for background counting. At the same time, the clinical baseline characteristic parameters such as age and thyroid volume etc. of patients with hyperthyroidism were collected. The consistency of 9mTcO4uptake rate before treatment and 131I-uptake rate after treatment, and the correlation between uptake rate of thyroid and baseline characteristic parameters were also analysed.
RESULTS: The uptake rate of 99mTcO4 was found positively correlated with 3 h-RAIU, 24 h-RAIU, 3 h/24 h conversion rate, thyroid volume, 131I activity FT3 and FT4, and showed negative correlation with age, effective half-life. (P<0.05). The uptake rate of 131I was found positively correlated with 3 h-RAIU, 24 h-RAIU, 3 h/24 h conversion rate, thyroid volume, 131I activity, FT3, FT4. (P<0.05). In patients with positive thyrotrophin receptor antibody (TRAb), a significant positive correlation between uptake rate of 99mTcO4 and 131I (P<0.05) was observed. There was a high consistency between pre-treatment uptake rate of 99mTcO4 and post-treatment uptake rate of 131I (P = 0.009; W = 0.7).
CONCLUSIONS: The corrected thyroid uptake rate is remarkably correlated with clinical characteristic parameters of patients, which can be used to comprehensively evaluate the comprehensive condition of patients with hyperthyroidism.


KEY WORDS: Radionuclide imaging; Iodine radioisotopes; Hyperthyroidism; Thyroid uptake rate; Radioactive iodine uptake (RAIU); Radioiodine therapy

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