The Quarterly Journal of Nuclear Medicine and Molecular Imaging 2021 Mar 09

DOI: 10.23736/S1824-4785.21.03324-0

Copyright © 2021 EDIZIONI MINERVA MEDICA

lingua: Inglese

Volumetric PET parameters are predictive for the prognosis of locally advanced cervical cancer

Adnan BUDAK ¹, Emine BUDAK ² ✉, Ahkam G. KANMAZ ¹, Abdurrahman H. INAN ¹, Gökhan TOSUN ¹, Emrah BEYAN ³, Onur S. ALDEMIR ⁴, Alper ILERI ⁵

¹ Department of Obstetrics and Gynecology, Tepecik Training and Research Hospital, Izmir, Turkey; ² Department of Nuclear Medicine, Suat Seren Chest Diseases and Surgery Training and Research Hospital, Izmir, Turkey; ³ Department of Obstetrics and Gynecology, Su Hospital, Izmir, Turkey; ⁴ Çınarlı Hospital, Department of Obstetrics and Gynecology, Izmir, Turkey; ⁵ Department of Obstetrics and Gynecology, Buca Seyfi Demirsoy Training and Research Hospital, Izmir, Turkey

BACKGROUND: The present study evaluates the relationship between PET/CT findings and survival in patients with locally advanced cervical cancer (LACC) with a squamous cell histology.
METHODS: The study included 70 patients with LACC (FIGO stage IB2-IVA). The relationship between pretreatment PET/CT parameters, age, stage, lymph node metastasis and survival was evaluated using the univariate and multivariate Cox proportional hazards model.
RESULTS: The mean age of the 70 patients was 57.4 years and the mean duration of follow-up was 33.6 months. Disease progression occurred in 36 patients and 32 patients died during the follow-up period. In the univariate analysis, MTV-P and TLG-P were found to be related to progression-free survival (PFS), and stage, MTV-P, TLG-P and SUVmax-Ps were found to be related to overall survival (OS). However, only MTV-P and TLG-P were found to be independent prognostic factors for both PFS and OS.
CONCLUSIONS: The present findings suggest that volumetric PET parameters (MTV-P, TLG-P) predict the progression and survival of the patients with LACC.

KEY WORDS: Locally advanced cervical cancer; FDG PET/CT; SUVmax; MTV; TLG