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The Quarterly Journal of Nuclear Medicine and Molecular Imaging 2020 Apr 14

DOI: 10.23736/S1824-4785.20.03238-0

Copyright © 2020 EDIZIONI MINERVA MEDICA

lingua: Inglese

Volumetric 68Ga-DOTA-TATE PET/CT for assessment of whole-body tumor burden as a quantitative imaging biomarker in patients with metastatic gastroenteropancreatic neuroendocrine tumors

Fiona OHLENDORF 1, Christoph HENKENBERENS 2, Thomas BRUNKHORST 1, Tobias L. ROSS 1, Hans CHRISTIANSEN 2, Frank M. BENGEL 1, Thorsten DERLIN 1

1 Department of Nuclear Medicine, Hannover Medical School, Hannover, Germany; 2 Department of Radiation Oncology, Hannover Medical School, Hannover, Germany


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BACKGROUND: A quantitative imaging biomarker is desirable to provide a comprehensive measure of whole-body tumor burden in patients with metastatic neuroendocrine tumors, and to standardize the evaluation of treatment-related changes. Therefore, we evaluated volumetric parameters for quantification of whole-body tumor burden from somatostatin receptor (SSR)- targeted PET/CT.
METHODS: 32 patients with metastastic grade1/grade 2 gastroenteropancreatic neuroendocrine tumors who underwent a 68Ga-DOTA-TATE PET/CT for staging of disease before initiation of peptide receptor radionuclide therapy were included in this retrospective cohort analysis. Volumetric parameters of tumor lesions, SSR-derived tumor volume (SSR-TV) and total lesion SSR (TL-SSR), were calculated for each patient using a computerized volumetric technique with a 40% SUVmax cut-off, and compared with serum chromogranin A (CgA) levels. Progression-free survival (PFS) was determined in relation to volumetric parameters. In a subgroup of 18 patients, the feasibility of volumetric parameters for treatment monitoring was evaluated.
RESULTS: Mean SSR-TV was 178±214 cm3 (range, 9-797 cm3), whereas mean TL-SSR was 4096±5191 cm3 (range, 61-19203 cm3). Baseline CgA levels were associated with whole- body tumor burden (SSR-TV, r=0.57, P=0.0008; and TL-SSR, r=0.43, P=0.01, respectively). PFS was shorter in patients with high SSR-TV and high TL-SSR (HR 5.16 (95% CI, 1.61- 29.67), P=0.009), and SSR-TV (P = 0.0067) and TL-SSR (P = 0.0215) emerged as the sole predictors of progression in regression analysis. Changes in CgA did not correctly identify treatment response (P=0.25).
CONCLUSIONS: SSR-derived volumetric parameters provide a quantitative imaging biomarker for whole-body tumor burden, and may hold potential as a clear-cut measure for assessment of treatment response.


KEY WORDS: Somatostatin receptor; PET/CT; Tumor volume; DOTA-TATE; Radionuclide therapy

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