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Rivista di Medicina Nucleare e Imaging Molecolare

A Journal on Nuclear Medicine and Molecular Imaging
Affiliated to the Society of Radiopharmaceutical Sciences and to the International Research Group of Immunoscintigraphy
Indexed/Abstracted in: Current Contents/Clinical Medicine, EMBASE, PubMed/MEDLINE, Science Citation Index (SciSearch), Scopus
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The Quarterly Journal of Nuclear Medicine and Molecular Imaging 2018 Mar 08

DOI: 10.23736/S1824-4785.18.03059-5


lingua: Inglese

Current application and future perspectives of PSMA PET imaging in prostate cancer

Francesco CECI 1, 2 , Paolo CASTELLUCCI 2, Stefano FANTI 2

1 Ahmanson Translational Imaging Division, Department of Molecular and Medical Pharmacology, University of California Los Angeles (UCLA), Los Angeles, CA, USA; 2 Nuclear Medicine, Azienda Ospedaliero-Universitaria di Bologna, Università di Bologna, Bologna, Italy


As precision medicine evolves, the contribution of molecular imaging to the management of prostate cancer (PCa) patients, especially for Positron Emission Tomography (PET) imaging, is gaining importance. Highly successful approaches to measure the expression of the prostate specific membrane antigen (PSMA) have been introduced recently. PSMA, the glutamate carboxypeptidase II (GCP-II), is a membrane bound metallo-peptidase that is overexpressed in 90-100% of PCa cells. Due to its selective over-expression, PSMA is a reliable tissue marker for prostate cancer and is considered an ideal target for tumor specific imaging and therapy. A variety of PET and SPECT probes targeting this peptide receptor have been introduced. These are undergoing extensive clinical evaluations. Initial results attest to a high accuracy for disease detection compared conventional radiology (CT or MRI) and other nuclear medicine procedure (choline PET or fluciclovine PET). However, prospective evaluation of the impact on patient management for PSMA-ligand PET and its impact on patient outcome is currently missing. Finally, PSMA inhibitors can be radio-labeled with diagnostic (68Ga-PSMA-11), or therapeutic nuclides (177Lu/225Ac PSMA-617) to be used as theranostic agent. Initial results showed that PSMA-targeted radioligand therapy (RLT) can potentially delay disease progression in metastatic castrate-resistant PCa. This review aims to explore the current application of PSMA based imaging in prostate cancer, reporting about main advantages and limitations of this new theranostic procedure. The future perspectives and potential the applications of this agent will be also discussed.

KEY WORDS: PMSA - Biochemical recurrence - Prostate cancer - Salvage therapy - PET

inizio pagina

Publication History

Article first published online: March 8, 2018
Manuscript accepted: March 6, 2018
Manuscript revised: February 19, 2018
Manuscript received: December 10, 2017

Per citare questo articolo

Ceci F, Castellucci P, Fanti S. Current application and future perspectives of PSMA PET imaging in prostate cancer. Q J Nucl Med Mol Imaging 2018 Mar 08. DOI: 10.23736/S1824-4785.18.03059-5

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