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THE QUARTERLY JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING

Rivista di Medicina Nucleare e Imaging Molecolare


A Journal on Nuclear Medicine and Molecular Imaging
Affiliated to the Society of Radiopharmaceutical Sciences and to the International Research Group of Immunoscintigraphy
Indexed/Abstracted in: Current Contents/Clinical Medicine, EMBASE, PubMed/MEDLINE, Science Citation Index (SciSearch), Scopus
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The Quarterly Journal of Nuclear Medicine and Molecular Imaging 2018 Feb 05

DOI: 10.23736/S1824-4785.18.03031-5

Copyright © 2018 EDIZIONI MINERVA MEDICA

lingua: Inglese

Prognostic impact of postoperative 123I-metaiodobenzylguanidine scintigraphy: added value of SPECT/CT and semiquantification of the uptake at the surgical site

Mathieu GAUTHÉ 1, 2 , Matthieu BRETON 1, Nina JEHANNO 1, Cécile CELLIER 3, Jean MICHON 4, Sabine SARNACKI 5, Gudrun SCHLEIERMACHER 3, Myriam WARTSKI 1

1 Médecine Nucléaire, Institut Curie, Paris, France; 2 Médecine Nucléaire, Hôpital Tenon, AP-HP, Paris, France; 3 Radiologie, Institut Curie, Paris, France; 4 Pédiatrie, Institut Curie, Paris, France; 5 Chirurgie Infantile, Hôpital Necker, Paris, France


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BACKGROUND: The aim of this study was to assess the prognostic value of postoperative 123I-MIBG scintigraphy, including systematic SPECT/CT and semiquantification of the uptake at the surgical site, in a prospective series of NB patients.
METHODS: Patients operated for neuroblastoma and who had benefited from postoperative 123I-MIBG scintigraphy were prospectively and consecutively included. Completeness of surgery was assessed on operative report. One month postoperative 123I-MIBG scintigraphy included planar acquisition and SPECT/CT. Semi-quantification of the 123I-MIBG SPECT/CT uptake at the surgical site was performed and ratios to reference (liver and mediastinum) areas were calculated.
RESULTS: Thirty patients were included between August 2012 and July 2015. Median follow-up was 36 months (range 10-98). Surgery was considered as complete in 23 patients and incomplete in 7 patients. Eight patients (26.7%) presented progressive disease (1 progression and 7 recurrences). Seven patients died (23.3%), all from NB. Six (20%) patients had positive 123I-MIBG scintigraphy (3 on planar acquisitions and 6 on SPECT/CT) and 24 patients had negative 123I-MIBG scintigraphy. Five of the 6 patients (83%) with positive 123I-MIBG scintigraphy presented progressive disease. Ratio of the uptake at the surgical site to mediastinum was strongly and independently correlated with disease-free interval and overall survival (p=0.02 and 0.01 respectively). The amplified MYCN status was also confirmed as correlated with poorer outcomes.
CONCLUSIONS: Postoperative 123I-MIBG scintigraphy including SPECT/CT and semiquantification of the uptake at the surgical site appeared to be a valuable prognostic tool in neuroblastoma.


KEY WORDS: Neuroblastoma - Paediatric - Survival

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Publication History

Article first published online: February 5, 2018
Manuscript accepted: February 2, 2018
Manuscript revised: January 2, 2018
Manuscript received: September 19, 2017

Per citare questo articolo

Gauthé M, Breton M, Jehanno N, Cellier C, Michon J, Sarnacki S, et al. Prognostic impact of postoperative 123I-metaiodobenzylguanidine scintigraphy: added value of SPECT/CT and semiquantification of the uptake at the surgical site. Q J Nucl Med Mol Imaging 2018 Feb 05. DOI: 10.23736/S1824-4785.18.03031-5

Corresponding author e-mail

mathieugauthe@yahoo.fr