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THE QUARTERLY JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING

Rivista di Medicina Nucleare e Imaging Molecolare


A Journal on Nuclear Medicine and Molecular Imaging
Affiliated to the Society of Radiopharmaceutical Sciences and to the International Research Group of Immunoscintigraphy
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The Quarterly Journal of Nuclear Medicine and Molecular Imaging 2017 Jul 27

DOI: 10.23736/S1824-4785.17.02976-4

Copyright © 2017 EDIZIONI MINERVA MEDICA

lingua: Inglese

Parkinson disease-related cortical and striatal cognitive patterns in dual time F-18 FP CIT: evidence for neural correlates between the caudate and the frontal lobe

Hye J. SON 1, 2, Young J. JEONG 1, 2, Hyun J. YOON 1, 2, Jae W. KIM 3, Go-E CHOI 2, Jong H. PARK 3, Do-Y. KANG 1, 2

1 Department of Nuclear Medicine, Dong-A University Medical Center, Dong-A University College of Medicine, Busan, Korea; 2 Institute of Convergence Bio-Health, Dong-A University, Busan, Korea; 3 Department of Neurology, Dong-A University Medical Center, Dong-A University College of Medicine, Busan, Korea


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BACKGROUND: Using dual time F-18 FP-CIT, we evaluated cortical perfusion, striatal binding and neuropsychological performance simultaneously in Parkinson’s disease (PD) with and without mild cognitive impairment (MCI), to investigate neural correlates between caudate and frontal cortex.
METHODS: According to the neuropsychological scores, subjects were classified into 26 healthy controls (HC), 38 PD-MCI (executive) (PE), 24 PD-MCI (non-executive) (PN) and 21 PD (motor) (PM). Scans were acquired at 10 minutes and 2 hours. Group differences of early perfusion and delayed binding were compared using SPM and volume of interest method. The relationships between neuropsychological variables and the striatal binding were investigated with correlation and regression analysis.
RESULTS: Compared with PM, PE showed decreased prefrontal perfusion and binding of both caudates (Right: p = 0.0010, Left: p = 0.014), but not of both putamens. Compared with PN, PE showed decreased binding of both caudates (Right: p = 0.001, Left: p = 0.005), but not in both putamens. Binding of both caudates correlated with the Stroop z-score, but not of both putamens. Executive score was a contributing factor to binding of the caudate, and not the putamen.
CONCLUSIONS: PE showed decreased prefrontal perfusion and caudate binding, supporting neural correlates between the caudate and the prefrontal cortex. Dopaminergic binding of the caudate, but not of the putamen, was related to executive scores. Caudate hypofunction was specific to executive domain. This is the first study that elucidated the clinical use of dual time F-18 FP-CIT for integrative evaluation of cognitive and motor function in PD.


KEY WORDS: Parkinson disease - (18F)FP-CIT - Frontal lobe - Mild cognitive impairment - PET/CT

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Publication History

Article first published online: July 27, 2017
Manuscript accepted: July 26, 2017
Manuscript revised: July 6, 2017
Manuscript received: January 26, 2017

Per citare questo articolo

Son HJ, Jeong YJ, Yoon HJ, Kim JW, Choi GE, Park JH, et al. Parkinson disease-related cortical and striatal cognitive patterns in dual time F-18 FP CIT: evidence for neural correlates between the caudate and the frontal lobe. Q J Nucl Med Mol Imaging 2017 Jul 27. DOI: 10.23736/S1824-4785.17.02976-4

Corresponding author e-mail

dykang@dau.ac.kr