Home > Riviste > The Quarterly Journal of Nuclear Medicine and Molecular Imaging > Fascicoli precedenti > The Quarterly Journal of Nuclear Medicine and Molecular Imaging 2020 June;64(2) > The Quarterly Journal of Nuclear Medicine and Molecular Imaging 2020 June;64(2):194-202

ULTIMO FASCICOLO
 

JOURNAL TOOLS

eTOC
Per abbonarsi
Sottometti un articolo
Segnala alla tua biblioteca
 

ARTICLE TOOLS

Publication history
Estratti
Permessi
Per citare questo articolo

 

ORIGINAL ARTICLE   

The Quarterly Journal of Nuclear Medicine and Molecular Imaging 2020 June;64(2):194-202

DOI: 10.23736/S1824-4785.18.03036-4

Copyright © 2018 EDIZIONI MINERVA MEDICA

lingua: Inglese

Clinical value of [18F]FDG-PET/CT and 3D-black-blood 3T-MRI for the diagnosis of large vessel vasculitis and single-organ vasculitis of the aorta

Vera WENTER 1 , Nora N. SOMMER 2, Hendrik KOOIJMAN 3, Stefan MAURUS 2, Marcus TREITL 2, Michael CZIHAL 4, Claudia DECHANT 5, Marcus UNTERRAINER 1, Nathalie L. ALBERT 1, Karla M. TREITL 2, 6

1 Department of Nuclear Medicine, University Hospital, LMU Munich, Munich, Germany; 2 Department of Radiology, University Hospital, LMU Munich, Munich, Germany; 3 Philips Healthcare, Hamburg, Germany; 4 Section of Vascular Medicine, Medical Clinic and Policlinic IV, University Hospital, LMU Munich, Munich, Germany; 5 Section of Rheumatology, Medical Clinic and Policlinic IV, University Hospital, LMU Munich, Munich, Germany; 6 German Center for Cardiovascular Disease Research (DZHK e. V.), Munich, Germany



BACKGROUND: We aimed to investigate the clinical value of a 3D-T1w turbo-spin-echo (TSE) sequence and [18F]fluorodeoxyglucose positron emission tomography/computed tomography ([18F]FDG-PET/CT) for the diagnosis of active large vessel vasculitis (LVV) and single-organ vasculitis (SOV) of the aorta.
METHODS: Twenty-four patients with suspected vasculitis who underwent MRI and PET/CT were retrospectively evaluated. MRI was analyzed for concentric contrast enhancement and wall thickening, and flow artifact intensity (4-point-scales). PET/CT analysis comprised qualitative, quantitative and semiquantitative methods. Imaging findings were correlated with final diagnosis derived from the clinical follow-up data.
RESULTS: Fifteen of 24 patients had a clinically confirmed active vasculitis, two had inactive vasculitis and 7 no vasculitis. [18F]FDG-PET/CT and 3D-T1w TSE-MRI revealed both a high diagnostic accuracy of 88% and 83%, respectively. In patients in whom both PET/CT and MRI showed concordant findings (19 patients), the accuracy increased to 95% with a high positive predictive value (92%) and negative predictive value (100%); thus, a correct diagnosis was obtained in 18 of 19 patients. Among the five patients with discordant findings PET/CT correctly identified the two patients without active vasculitis while rated false positive on MRI. Of the three remaining patients with active vasculitis, two were correctly identified by MRI and one by PET/CT.
CONCLUSIONS: 3D-T1w TSE-MRI and [18F]FDG-PET/CT are both useful in the diagnosis of active vasculitis with high diagnostic accuracies. The diagnostic accuracy was even optimized by combining the two analysis methods. Therefore, there might be substantial potential for the application of whole-body hybrid PET/MRI in the evaluation of vasculitis in future studies.


KEY WORDS: Vasculitis; Fluorodeoxyglucose F18; Positron emission tomography computed tomography; Magnetic resonance imaging; Inflammation; Giant cell arteritis

inizio pagina