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REVIEW  IMAGING INFLAMMATION IN CARDIOVASCULAR DISEASES 

The Quarterly Journal of Nuclear Medicine and Molecular Imaging 2020 March;64(1):21-34

DOI: 10.23736/S1824-4785.20.03231-8

Copyright © 2020 EDIZIONI MINERVA MEDICA

lingua: Inglese

Inflammation imaging to define vulnerable plaque or vulnerable patient

Jonathan VIGNE 1, 2, 3 , Fabien HYAFIL 2, 4

1 Department of Nuclear Medicine, CHU de Caen Normandie, Normandie University (UNICAEN), Caen, France; 2 INSERM U1148, Laboratory for Vascular Translational Science (LVTS), DHU FIRE, University of Paris, Paris, France; 3 Department of Pharmacy, CHU de Caen Normandie, Normandie University (UNICAEN), Caen, France; 4 Department of Nuclear Medicine, Bichat University Hospital, Paris, France



The role of nuclear imaging in the characterization of high-risk atherosclerotic plaque is increasing thanks to its high sensitivity to detect radiopharmaceuticals signal in tissues. Currently, 2-deoxy-2-[18F]fluoro-D-glucose ([18F]FDG) is the most studied and widely used radiopharmaceutical for the molecular imaging of atherosclerotic plaques with positron emission tomography (PET). [18F]FDG PET is a valuable tool to non-invasively detect, monitor and quantify inflammatory processes occurring in atherosclerotic plaques. The aim of this review is to gather insights provided by [18F]FDG PET to better understand the role of inflammation in the definitions of the vulnerable plaque and the vulnerable patient. Alternatives radiopharmaceuticals targeting inflammation and other potential high-risk plaque related processed are also discussed.


KEY WORDS: Atherosclerosis; Inflammation; Nuclear medicine; Molecular imaging

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