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The Quarterly Journal of Nuclear Medicine and Molecular Imaging 2018 June;62(2):209-19

DOI: 10.23736/S1824-4785.17.02807-2

Copyright © 2015 EDIZIONI MINERVA MEDICA

lingua: Inglese

Diagnostic performances of [18F]fluorocholine positron emission tomography in brain tumors

Martina SOLLINI 1 , Roberto SGHEDONI 2, Paola A. ERBA 3, Silvio CAVUTO 4, Armando FROIO 1, Gianni DE BERTI 5, Anna PISANELLO 6, Alessandro FRATERNALI 1, Michele IORI 1, Corrado IACCARINO 7, 8, Mauro IORI 2, Mattia ASTI 1, Angelina FILICE 1, Annibale VERSARI 1

1 Unit of Nuclear Medicine, Santa Maria Nuova Hospital, Institute for Research and Care of Reggio Emilia, Reggio Emilia, Italy; 2 Unit of Medical Physics, Santa Maria Nuova Hospital, Institute for Research and Care of Reggio Emilia, Reggio Emilia, Italy; 3 Regional Center of Nuclear Medicine, University of Pisa, Pisa, Italy; 4 Unit of Infrastructure Research and Statistics, Santa Maria Nuova Hospital, Institute for Research and Care of Reggio Emilia, Reggio Emilia, Italy; 5 Neuroradiology Section, Villa Verde Clinic, Reggio Emilia, Italy; 6 Unit of Neurology, Santa Maria Nuova Hospital, Institute for Research and Care of Reggio Emilia, Reggio Emilia, Italy; 7 Unit of Neurosurgery and Neurotraumatology, Parma University Hospital, Parma, Italy; 8 Unit of Emergency Neurosurgery, Santa Maria Nuova Hospital, Institute for Research and Care of Reggio Emilia, Reggio Emilia, Italy


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BACKGROUND: Brain tumors characterization by molecular imaging that allows the depiction of brain lesions metabolic pattern is crucial. Our study aimed to: 1) to evaluate the diagnostic performances of [18F]fluoroethylcholine positron emission tomography/computed tomography ([18F]FECH PET/CT), and 2) correlate PET imaging derived parameters of [18F]FECH to survival in brain tumors.
METHODS: From 2009 to 2012, we enrolled 30 patients who underwent [18F]FECH PET/CT. Final diagnosis was established by clinical and radiological follow-up.
RESULTS: Final diagnosis was consistent with tumor disease in 27/30 cases. In 3/30 cases tumor disease was ruled out. [18F]FECH PET/CT resulted true positive and negative in 21/30 and 9/30 patients, respectively. Sensitivity, specificity, positive predictive value, negative predictive value and accuracy of [18F]FECH PET/CT were 78%, 100%, 100%, 33%, and 80%, respectively. Mean and maximum standardized uptake value (SUVmean and SUVmax) resulted statistically correlated to histology (P=0.0255 and P=0.0222, respectively). Using a SUVmax cut-off of 2.0 or 3.2, we distinguished between low- and high-grade gliomas with a good specificity (70% and 80%, respectively). SUVmax and histology resulted correlated to overall survival and disease related survival at multivariate analysis.
CONCLUSIONS: Our results, worthy of further investigations, show high diagnostic performances of [18F]FECH PET/CT, and a correlation between PET imaging derived parameters and survival.


KEY WORDS: Brain Neoplasm - Glioma - Molecular Imaging - Fluorocholine - Positron-Emission Tomography

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