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REVIEW  PRECLINICAL IMAGING 

The Quarterly Journal of Nuclear Medicine and Molecular Imaging 2017 March;61(1):1-18

DOI: 10.23736/S1824-4785.16.02951-4

Copyright © 2016 EDIZIONI MINERVA MEDICA

lingua: Inglese

Preclinical imaging anesthesia in rodents

Giancarlo VESCE 1, Fabiana MICIELI 1, Ludovica CHIAVACCINI 2

1 Department of Veterinary Medicine and Animal Production, Federico II University, Naples, Italy; 2 Ryan Veterinary Hospital, University of Pennsylvania, Philadelphia, PA, USA


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Despite the outstanding progress achieved by preclinical imaging science, laboratory animal anesthesia remains quite stationary. Ninety percent of preclinical imaging studies are carried on small rodents (mice and rats) anesthetized by outdated injectable and/or inhalation agents. A need for imaging awake (conscious) animals is questionably registered mainly for brain research, for phMRI and for accomplishing pain and analgesia studies. A need for improving current rodent anesthesia protocols and for enforcing the 3Rs paradigm is sought. Patient monitoring throughout the procedure and recovery phases, as well as vital parameter’s data must be recorded in basic consciousness states and during imaging sessions. A multidrug approach is suggested to overcome the limits of monoanesthesia and well-timed physiological data are required to ground findings and to interpret imaging data.


KEY WORDS: Molecular imaging - Rodentia - Anesthesia and analgesia - Animal experimentation

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