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REVIEWS  MONOCLONAL ANTIBODIES FOR DIAGNOSIS AND THERAP Y DECISION MAKING IN INFLAMMATION/INFECTION 

The Quarterly Journal of Nuclear Medicine and Molecular imaging 2010 December;54(6):582-98

Copyright © 2011 EDIZIONI MINERVA MEDICA

lingua: Inglese

Targeting NCA-95 and other granulocyte antigens and receptors with radiolabeled monoclonal antibodies (Mabs)

Meller J., Liersch T., Oezerden M. M., Sahlmann C. O., Meller B.

1 Department of Nuclear Medicine, University of Göttingen, Göttingen, Germany; 2 Department of General and Visceral Surgery, University of Göttingen, Göttingen, Germany


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During the last decade considerable effort has been made in the research for in vivo techniques of labeling neutrophils with peptides, labeled cytokines and 99mTc-labeled antigranulocyte monoclonal antibodies (AG-Mabs). In general the advantage of in vivo labeling is the simplicity of this approach compared with in vivo techniques. Three of these AG-Mabs have been evaluated in clinical studies: Besilesomab (Scintimun®), Sulesomab (Leucoscan®) and Fanolesomab (Leu-Tech®). White blood cells (WBCs) radiolabeled with AG-Mabs do not show the same behaviour as in vivo labeled white blood cells. Especially 99mTc-Sulesomab and 99mTc-Besilesomab image infectious foci mainly by non-specific extravasation with secondary binding to postmigratory leukocytes already present at the site of infection.

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