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The Quarterly Journal of Nuclear Medicine and Molecular imaging 2010 October;54(5):564-9

Copyright © 2010 EDIZIONI MINERVA MEDICA

lingua: Inglese

Exploring dopaminergic activity in ring chromosome 20 syndrome: a SPECT study

Del Sole A. 1, 2, Chiesa V. 3, Lucignani G. 1, 2, Vignoli A. 3, Giordano L. 4, Lecchi M. 1, 2, Canevini M. P. 3

1 Department of Biomedical Sciences and Technologies and Center of Molecular and Cellular Imaging (IMAGO), University of Milan, Milan, Italy; 2 Department of Diagnostic Services, Unit of Nuclear Medicine, San Paolo Hospital, Milan, Italy; 3 Department of Medicine, Surgery and Dentistry, University of Milan, Regional Epilepsy Center, San Paolo Hospital, Milan, Italy; 4 Neuropschiatry Unit, Spedali Civili, Brescia, Italy


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AIM: Several lines of evidence indicate that the dopaminergic system may play a role in the propagation of epileptic seizures and, indeed, DOPA metabolism impairment has recently been demonstrated in PET studies of ring chromosome 20 [r(20)] patients. We conducted a study looking for correlations between r(20) mosaicism, other clinical variables and both pre-synaptic dopamine transporter (DAT) expression and post-synaptic D2 receptor density.
METHODS: Five patients with r(20) and epilepsy were enrolled in the study. DAT expression and D2 density were measured by single photon emission tomography (SPECT) imaging with 185 MBq of [123I]ioflupane and [123I]IBZM, respectively, on different days. Linear correlations between r(20) mosaicism, clinical variables and binding of [123I]ioflupane or [123I]IBZM were examined.
RESULTS: A significant correlation between seizure frequency and r(20) mosaicism was detected (r=0.903, P<0.05), along with a negative correlation between r(20) mosaicism and binding of [123I]ioflupane in the putamen and in the caudate nucleus (r=-0.692 and r=-807; P<0.05). Seizure frequency was positively correlated with post-synaptic D2 density (r=0.925, P<0.05).
CONCLUSION: Striatal neurons are involved in r(20) epilepsy; the relationship found between r(20) mosaicism and DAT expression suggests that drugs acting on the dopaminergic system could have a place in the treatment of this rare form of epilepsy.

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