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The Quarterly Journal of Nuclear Medicine and Molecular imaging 2010 October;54(5):500-9

Copyright © 2010 EDIZIONI MINERVA MEDICA

lingua: Inglese

Hypoxia PET/CT imaging: implications for radiation oncology

Arabi M., Piert M.

Department of Radiology, Division of Nuclear Medicine, University of Michigan Health System, Ann Arbor, MI, USA


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Hypoxia, a condition of reduced partial pressure of oxygen in tissue, is an important determinant of poor tumor response to radiation treatment. Many invasive and non-invasive methods and approaches have been investigated to detect tumor hypoxia for response prediction and to facilitate modulation of radiation treatment. In this review we discuss the biological consequences of tumor hypoxia, methods of measuring regional tumor hypoxia with positron emission tomography (PET) tracers and applications for radiation oncology.

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