REVIEWS  AN OVERVIEW OF THE RADIOPHARMACOLOGY FIELD TO DATE 

The Quarterly Journal of Nuclear Medicine and Molecular Imaging 2008 September;52(3):215-21

Copyright © 2008 EDIZIONI MINERVA MEDICA

lingua: Inglese

Small animal PET in preclinical studies: opportunities and challenges

Riemann B., Schäfers K. P., Schober O., Schäfers M.

Department of Nuclear Medicine University Hospital, Münster, Germany

The process of drug and molecular imaging development is strongly influenced by the revolution of non-invasive imaging techniques. Small animal positron emission tomography (PET) has the potential to accelerate and streamline drug and molecular imaging discovery and development by preselection of suitable candidate molecules. Due to its significantly improved spatial resolution and its quantitative nature, compared to other techniques small animal PET can be employed to bridge the in vitro, through to preclinical and clinical imaging in humans.